Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 216-245-3 | CAS number: 1533-45-5
Table No. I
Summary of Clinical Signs of Toxicity and Mortality
Test System : Sprague Dawley Rat
Sex : Male
Total Number of
Period of signs in days
From - to
No clinical signs observed
1 - 5
Day 0 - Day 14
Sex : Female
6 - 10
Table No. II
Summary of Evaluation of Dermal Reaction
Sex : Male
Period of signs
No dermal reaction observed
Mean Body Weight and Percent Body Weight Gain (g)
(mg/kg body weight)
Body weight Day 0
Body weight Day 7
% body weight gain
Body weight Day 14
day 7- 14
day 0- 14
Summary of Gross Pathological Findings
Gross Pathological Findings
No abnormality detected
TS = Terminal Sacrifice
The acute dermal toxicity profile of the given test chemical in Sprague Dawley rats according to OECD Guideline 402 (Acute Dermal Toxicity).
The test item was applied to shorn skin of 5 male and 5 female animals at 2000 mg/kg body weight. Administration of the test item at 2000 mg/kg did not result in any skin reaction at the site of application during the study period of 14 days. Administration of the test item did not result in any signs of toxicity and mortality during the study period of 14 days. Animals exhibited normal body weight gain through the study period of 14 days. Gross pathological examination did not reveal any abnormalities attributable to the treatment.
Therefore, the LD50 value was considered to be >2000 mg/kg bw, when male and female Sprague Dawley rats were occlusively treated with the given test chemical by dermal application following 14 days of observation period according to OECD Guideline 402 (Acute Dermal Toxicity).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again