Registration Dossier
Registration Dossier
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EC number: 265-742-1 | CAS number: 65405-72-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Abstract only.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The acute toxicity of the test substance was investigated in Wistar rats with an average weight of 150 g. The test substance was administered by oral gavage with 0.5 mL/100 g body weight, to a group of 10 rats (5 male and 5 female) followed by a 10 day observation period.
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- 1,2,3,4,4a,7,8,8a-octahydro-2,4a,5,8a-tetramethyl-1-naphthyl formate
- EC Number:
- 265-742-1
- EC Name:
- 1,2,3,4,4a,7,8,8a-octahydro-2,4a,5,8a-tetramethyl-1-naphthyl formate
- Cas Number:
- 65405-72-3
- Molecular formula:
- C15H24O2
- IUPAC Name:
- 1,2,3,4,4a,7,8,8a-octahydro-2,4a,5,8a-tetramethyl-1-naphthyl formate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: Average weight of 150 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- 0.5 mL/ 100 g body weight
- No. of animals per sex per dose:
- Five/sex/dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 10 days
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 other: g/kg body weight
- Based on:
- test mat.
- Mortality:
- There was no mortality during the study.
- Clinical signs:
- other: Relatively minor symptoms such as drowsiness, slight diarrhoea and slight piloerection. All toxic effects were resolved 24 hours after administration.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 of the test substance was > 5 g/kg body weight.
- Executive summary:
Method
The acute toxicity of the test substance was investigated on Wistar rats with an average weight of 150g. The product was administered by stomach tube at 0.5mL/100g body weight, to a group of 10 rats (5 male and 5 female).
Results
Administration of a single dose of 0.5mL/100 g of bodyweight of the product produced no mortality during the10 days following the application of the substance.
Relatively minor symptoms such as drowsiness, accompanied with a slight diarrhea and low piloerection was demonstrated. Any toxic effects disappeared within 24 hours of applying the test substance.
The LD50 of the product is > 5 g/kg body weight (rat) and is therefore regarded as very low toxicity.
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