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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
No data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Abstract only.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report date:
1971

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The acute toxicity of the test substance was investigated in Wistar rats with an average weight of 150 g. The test substance was administered by oral gavage with 0.5 mL/100 g body weight, to a group of 10 rats (5 male and 5 female) followed by a 10 day observation period.
GLP compliance:
not specified
Test type:
other: No data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2,3,4,4a,7,8,8a-octahydro-2,4a,5,8a-tetramethyl-1-naphthyl formate
EC Number:
265-742-1
EC Name:
1,2,3,4,4a,7,8,8a-octahydro-2,4a,5,8a-tetramethyl-1-naphthyl formate
Cas Number:
65405-72-3
Molecular formula:
C15H24O2
IUPAC Name:
1,2,3,4,4a,7,8,8a-octahydro-2,4a,5,8a-tetramethyl-1-naphthyl formate
Test material form:
liquid

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: Average weight of 150 g

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Doses:
0.5 mL/ 100 g body weight
No. of animals per sex per dose:
Five/sex/dose
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 10 days

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 other: g/kg body weight
Based on:
test mat.
Mortality:
There was no mortality during the study.
Clinical signs:
Relatively minor symptoms such as drowsiness, slight diarrhoea and slight piloerection. All toxic effects were resolved 24 hours after administration.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The LD50 of the test substance was > 5 g/kg body weight.
Executive summary:

Method

The acute toxicity of the test substance was investigated on Wistar rats with an average weight of 150g. The product was administered by stomach tube at 0.5mL/100g body weight, to a group of 10 rats (5 male and 5 female).

 

Results

Administration of a single dose of 0.5mL/100 g of bodyweight of the product produced no mortality during the10 days following the application of the substance.

Relatively minor symptoms such as drowsiness, accompanied with a slight diarrhea and low piloerection was demonstrated. Any toxic effects disappeared within 24 hours of applying the test substance.

The LD50 of the product is > 5 g/kg body weight (rat) and is therefore regarded as very low toxicity.