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EC number: 203-602-3 | CAS number: 108-64-5
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2014-12-08 to 2015-03-03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- (1995)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 1.76 g/L
- Loading of aqueous phase:
- 25 g/L
- Incubation duration:
- >= 24 - <= 72 h
- Temp.:
- 20 °C
- pH:
- 6.5
- Details on results:
- Preliminary Test (non GLP): The determined solubility was in the range of 2 – 5 g/L.
- Conclusions:
- The solubility of the test item was determined to be 1.76 g/L (pH 6.5) at 20+-0.5°C.
- Executive summary:
The test item has a water solubility of 1.76 g/L (pH 6.5) at 20± 0.5 °C as determined by flask method according to Regulation EC No. 440/2008 Method A.6., OECD Test Guideline 105 (1995).
Reference
Water solubility results at 20°C for the Test Item
Preincubation time |
Replicate No. |
Ethyl Isovalerate [g/L] |
|
Concentration1) |
Mean |
||
24 h |
1 |
1.78 |
1.74 |
|
2 |
1.70 |
|
48 h |
1 |
1.81 |
1.79 |
|
2 |
1.77 |
|
72 h |
1 |
1.80 |
1.75 |
|
2 |
1.70 |
1.75 |
Mean (24-72 h) |
|
|
1.76 |
Deviation [%] (24-72h)2) |
|
|
|
1) Mean value of double injection
2) Calculated according to Deviation [%] = 100*(max value – min value)/(min value)
Check of temperature:
Temperature at incubation phase, 30°C and thermostatisation phase, 20°C (measured hourly)
Intended temperature [°C] |
Measured temperature [°C] |
||
|
Min |
Max |
Mean value ± SD |
30.0 ± 0.5 |
29.62 |
30.09 |
30.03 ± 0.06 |
20.0 ± 0.5 |
19.96 |
20.21 |
20.04 ± 0.06 |
pH value of the Test Mixture
Test temperature [°C] |
Preincubation time [h] |
Replicate |
Measured pH |
Mean value |
20 |
24 |
1 |
6.340 |
6.5 |
2 |
6.301 |
|||
48 |
1 |
6.683 |
||
2 |
6.583 |
|||
72 |
1 |
6.713 |
||
2 |
6.658 |
|||
Control |
|
|
6.745 |
- |
Description of key information
Water solubility: 1.76 g/L at 20 °C by flask method.
Key value for chemical safety assessment
- Water solubility:
- 1.76 g/L
- at the temperature of:
- 20 °C
Additional information
The test item has a water solubility of 1.76 g/L (pH 6.5) at 20± 0.5 °Cas determined by flask method according to Regulation EC No. 440/2008 Method A.6., OECD Test Guideline 105 (1995).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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