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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2014-12-08 to 2015-03-03
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reference:
Composition 0
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
(1995)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Test material information:
Composition 1
Key result
Water solubility:
1.76 g/L
Loading of aqueous phase:
25 g/L
Incubation duration:
>= 24 - <= 72 h
Temp.:
20 °C
pH:
6.5
Details on results:
Preliminary Test (non GLP): The determined solubility was in the range of 2 – 5 g/L.

Water solubility results at 20°C for the Test Item

Preincubation time

Replicate No.

Ethyl Isovalerate [g/L]

Concentration1)

Mean

24 h

1

1.78

1.74

 

2

1.70

 

48 h

1

1.81

1.79

 

2

1.77

 

72 h

1

1.80

1.75

 

2

1.70

1.75

Mean (24-72 h)

 

 

1.76

Deviation [%] (24-72h)2)

 

 

 

1)        Mean value of double injection

2)        Calculated according to Deviation [%] = 100*(max value – min value)/(min value)

 

Check of temperature:

Temperature at incubation phase, 30°C and thermostatisation phase, 20°C (measured hourly)

Intended temperature [°C]

Measured temperature [°C]

 

Min

Max

Mean value ± SD

30.0 ± 0.5

29.62

30.09

30.03 ± 0.06

20.0 ± 0.5

19.96

20.21

20.04 ± 0.06

 

pH value of the Test Mixture 

Test temperature [°C]

Preincubation time [h]

Replicate

Measured pH

Mean value

20

24

1

6.340

6.5

2

6.301

48

1

6.683

2

6.583

72

1

6.713

2

6.658

Control

 

 

6.745

-

 

Conclusions:
The solubility of the test item was determined to be 1.76 g/L (pH 6.5) at 20+-0.5°C.
Executive summary:

The test item has a water solubility of 1.76 g/L (pH 6.5) at 20± 0.5 °C as determined by flask method according to Regulation EC No. 440/2008 Method A.6., OECD Test Guideline 105 (1995).

Description of key information

Water solubility: 1.76 g/L at 20 °C by flask method.

Key value for chemical safety assessment

Water solubility:
1.76 g/L
at the temperature of:
20 °C

Additional information

The test item has a water solubility of 1.76 g/L (pH 6.5) at 20± 0.5 °Cas determined by flask method according to Regulation EC No. 440/2008 Method A.6., OECD Test Guideline 105 (1995).