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EC number: 213-944-5 | CAS number: 1068-27-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2015-05-20 to 2015-06-18
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- (May 2008)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- (January 2001)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- other: HPLC screening
- Radiolabelling:
- no
- Test temperature:
- 25 °C
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: HPLC system: LaChrom Elite
- HPLC Conditions: Column: LiChrospher 100 CN (5µm) 250x4, No: 933278
Mobile Phase: Acetonitrile : Water = 55 : 45 (v/v)
Flow: 0.8 mL/min
Injection volume: 5 µL
Temperature: 25 °C
Detector: 230 nm (Reference standards)
Detector: 205 nm (DYBP-85-WO)
REFERENCE SUBSTANCES
- Identity: Sodium nitrate, Acetanilide, Methyl benzoate, Isoproturon, Linuron, Naphthalene, Pyrazophos, Phenantrene, DDT
DETERMINATION OF RETENTION TIMES
Three series of the above-mentioned reference solutions were measured with two parallel injections, each. Three series of the test item solution (in acetonitrile and in eluent) were measured with two parallel injections in booth, each. The retention times were determined. The three calibration series and three test item series were measured alternately. For the determination of t0 (t0 = retention time of the unretarded component) three series of Sodium Nitrate solution were injected two times.
EVALUATION
Chromatograms were evaluated using EZChrom Elite chromatogram processor software. Calculations were carried out using Microsoft Office Excel.
The capacity factors, k were calculated from the retention times (tR) of the selected reference substances and the dead time (t0): k = (tR-t0)/t0
Then the log k data of the reference substances were plotted against their log Koc values. The regression coefficients (a, b) were determined by linear regression calculation using the least squares method.
The log Koc value of the test item was calculated, using these regression coefficients and the capacity factor of the test item: log k = a + b*log Koc; where: Koc = adsorption coefficient; a = constant, b = slope; k = capacity factor - Key result
- Type:
- log Koc
- Value:
- 4.06
- Temp.:
- 25 °C
- Remarks on result:
- other: 95 % confidence interval: 0.012
- Key result
- Type:
- Koc
- Value:
- 11 474
- Temp.:
- 25 °C
- Remarks on result:
- other: 95 % confidence interval: 276
- Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient Koc was estimated to be 11474 ± 276 (95 % confidence interval) and the log Koc was 4.06 ± 0.012 (95 % confidence interval).
- Executive summary:
The purpose of the study was to estimate the adsorption coefficient, Koc of the test item using HPLC according to OECD 121 and EU Methof A.19. This method is applicable for substances, which have log Koc value ranging from 1.5 to 5.0. The adsorption coefficient Koc was estimated to be 11474 ± 276 (95 % confidence interval) and the log Koc was 4.06 ± 0.012 (95 % confidence interval).
Reference
Description of key information
The adsorption coefficient Koc was estimated to be 11474 ± 276 (95 % confidence interval) and the logKoc was 4.06 ± 0.012 (95 % confidence interval).
Key value for chemical safety assessment
- Koc at 20 °C:
- 11 474
Additional information
The adsorption coefficient of the test substance was estimated on soil and on sewage sludge using High Performance Liquid Chromatography (HPLC). The test was conducted in accordance with the OECD guideline 121 and EU method C. 19. This method is applicable for substances, which have log Koc value ranging from 1.5 to 5.0. The adsorption coefficient Koc was estimated to be 11474 ± 276 (95 % confidence interval) and the log Koc was 4.06 ± 0.012 (95 % confidence interval).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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