Registration Dossier

Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Human patch test

Data source

Reference
Reference Type:
publication
Title:
Allergic contact dermatitis from a perinone-type dye C.I. Solvent Red 179 in spectacle frames
Author:
Tsunoda T, Kaniwa MA, Shuno M
Year:
2001
Bibliographic source:
Contact Dermatitis, 2001, 45, 166–167

Materials and methods

Type of sensitisation studied:
skin
Study type:
case report
Principles of method if other than guideline:
A patch test was performed with C.I. solvent Red 179 (CAS no 6829-22-7) on a 61-year old Japanese woman who developed itchy scaly erythema over the ears where the earpieces of her spectacle frames touched.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
no data

Method

Type of population:
general
Controls:
yes
Route of administration:
dermal

Results and discussion

Results of examinations:
Positive reactions were obtained to scrapings of the earpieces, coloring agent 1% pet., Solvent Red 179 1% pet.(CAS no 6829-22-7) and Solvent Orange 60 1% pet. at D3. She was negative to Solvent Red 151. Control patch tests with scrapings, coloring agents and 3 dyes were negative in 5 normal
controls. The patient reacted to Solvent Red 179 and Solvent Orange 60, although the causative earpieces did not contain Solvent Orange 60. Thus, the reaction to Solvent Orange 60 in our case is concluded as being a cross-reaction with Solvent Red 179.

Any other information on results incl. tables

The 1st case of allergic contact dermatitis from C.I. Solvent Red 179 used in the earpieces of spectacle frames, with cross-reaction to C.I. Solvent Orange 60 is reported.

Applicant's summary and conclusion

Executive summary:

In a case report of a 61-year-old Japanese woman who developed itchy scaly erythema over the ears where the earpieces of her spectacle touched, as allergic contact reagent C.I. Solvent Red 179 was identified in a patch test.