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EC number: 200-677-4 | CAS number: 68-11-1
Table 1: Generation and characterization of chamber atmosphere (aerosolization of the neat test article) - Mean values
Target Conc. (mg/m³)
Nominal concentration (mg/m³)a
Gravimetric Conc. (mg/m³)
Analytical concentration (mg/m³)
Test article supply (ml/min)
Inlet Air Flow (l/min)
Exhaust Air Flow (l/min)
Rel. Humidity (mean, %)
Aerosol Mass < 3 µm (%)
Mass recovered (mg/m³)
MMAD = Mass Median Aerodynamic Diameter, GSD = Geometric Standard Deviation; -- = not applicable. Recovery: Analytical concentration relative to nominal concentration. a) For calculation a specific density D204= 1.32 g/cm³ was used.
Table 2: Summary of acute inhalation toxicity - 4 hour exposure to aerosolized test substance
Onset and Duration of Signs
Onset of Mortality
Rectal Temperature (°C)
1 / m
0 / 0 / 5
2 / m
0 / 5 / 5
3 / m
0d – 2d
4 / m
1 / 5 / 5
5 / m
5 / 4 / 5
1 / f
2 / f
0d (5h) – 3d
3 / f
0d – 12d
4 / f
5 / 5 / 5
5 / f
N = group assignment, m = males, f = females, * = p < 0.05, ** = p < 0.01
Values given in the 'Toxicological results' column are:
1st = number of dead animals.
2nd = number of animals with signs after cessation of exposure.
3rd = number of animals exposed.
A study on the acute inhalation toxicity of THIOGLYCOLIC ACID on rats has been conducted in accordance with OECD Guideline No. 403, EU Directive 92/69/EEC, OPPTS 870.1300 and Japan MAFF, Notification No. 12 Nousan-8147. Four groups of rats were nose-only exposed to a mean aerosol concentrations of 284, 837, 1441, and 3629 mg/m³ air. The liquid aerosol generated (aerosolization of the undiluted test article) was respirable to rats and all
concentration data represent actual concentrations of the test substance in the rats breathing zone.Internationally recognized recommendations such as of SOT (1992) were fulfilled, in regard to the respirability of the aerosol generated, i.e. the MMAD was <4 µm (MMAD 2.5-3.1 µm, GSD»2.1).
Mortality occurred at exposure concentrations equal to and exceeding 1441 mg/m³. In the range of the LC50-concentration, female rats appeared to be more susceptible when compared to male rats. Based on the calculations obtained by the probit standard modele, the approximate LC50for males and females is 1891 and 1094 mg/m³, respectively, and the combined LC50 is 1388 mg/m3 . Mortality occurred up to the first postexposure day. The clinical signs observed included the following findings: bradypnea, labored breathing patterns, irregular breathing patterns, tachypnea, nasal discharge (serous), nose: reddened, nose: gray discolorations, nose: red encrustations, muzzle: red encrustations, nostrils: red encrustations, stridor, piloerection, hair-coat ungroomed, cyanosis, emaciation, motility reduced, limp, apathy, tremor (hind limbs), paralysis (all legs), high-legged gait, flaccidity (all limbs) , posture squatted, prostration, corneal opacity, tremor (entire body), reduced reflexes, decreased body weights, and hypothermia. The duration of clinical signs was governed by respiratory distress and behavioral abnormalities. At the end of the postexposure period most rats appeared to be clinically normal. Necropsy findings were suggestive that lung damage was causally related to mortality. .
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