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EC number: 257-573-7
CAS number: 51981-21-6
The nominal concentration of GLDA-Na4,
calculated from the test material flow and the air
flow was 33.3 g/m3 (66.6 g/m3
solution of 50 wt% GLDA-Na4), indicating a generation efficiency of 13%.
GLDA-Na4 was evaluated
for its acute inhalation toxicity potential in rats. The study was
performed in accordance with OECD Guideline 403 (Acute Inhalation
Toxicity). The study was designed and performed according to Good
Laboratory Practice Standards. Five
males and five females were exposed for four hours to an aerosol
generated from the test material at a target concentration of 5 g/m3. A
concentration of ca. 4.3 g/m3 was considered the technically highest
attainable concentration, taking into account a respirable particle size
(MMAD between 1 and 4 micron). The actual concentration of the test
compound turned out to be 4.2 g/m3; the MMAD was 2.8 micron and gsd was
2.7. There was no mortality during the study. Clinical signs included
slightly decreased breathing rate during exposure and a soiled fur of
the head, neck, back, and/or abdomen shortly after exposure, which were
no longer evident on Day 2. Sniffing was noticed in 4 animals shortly
after exposure, in 7 animals on day 1 and in 1 animal on day 2. A
discharge from the eyes was seen in a single animal on day 1. No other
abnormalities were observed in the 14-day observation period. Body
weight gain was as expected for animals of this age and strain and no
macroscopic abnormalities were found.
The acute (4 -h)
inhalation LC50 of GLDA-Na4 was determined to be greater than
4.2 mg/L in males and females. This was the technically highest
attainable concentration. As no mortality occurred at this
concentration, no classification is needed according to OECD-GHS.
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