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Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from safety assessment report

Data source

Reference
Reference Type:
secondary source
Title:
SIDS Dossier for CAS no: 6358-85-6
Author:
OECD SIDS
Year:
2003
Bibliographic source:
OECD HPV Chemical Programme, SIDS Dossier, approved at SIAM 16 (27/05/2003)

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Principles of method if other than guideline:
An eye irritation study of C. I. Pigment Yellow 12 (CAS no: 6358-85-6) was conducted on rabbits to determine the degree of eye irritation according to OECD Guide-line 405 “Acute Eye Irritation/Corrosion”.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
2,2'-[(3,3'-dichlorobiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis(3-oxo-N-phenylbutanamide)
Cas Number:
6358-85-6
Molecular formula:
C32H26Cl2N6O4
IUPAC Name:
2,2'-[(3,3'-dichlorobiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis(3-oxo-N-phenylbutanamide)
Test material form:
solid: particulate/powder
Details on test material:
- Name of test material (as cited in study report): C. I. Pigment Yellow 12
- Molecular formula: C32H26Cl2N6O4
- Molecular weight: 629.5014 g/mol
- Substance type: organic
- Physical state: solid
Specific details on test material used for the study:
- Name of test material (as cited in study report): C. I. Pigment Yellow 12
- Molecular formula: C32H26Cl2N6O4
- Molecular weight: 629.5014 g/mol
- Substance type: organic
- Physical state: solid

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No data available

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
No data available
Duration of treatment / exposure:
No data available
Observation period (in vivo):
No data available
Duration of post- treatment incubation (in vitro):
No data available
Number of animals or in vitro replicates:
No data available
Details on study design:
No data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
The chemical C. I. Pigment Yellow 12 (CAS no: 6358-85-6) was considered as not irritating to the eye of rabbits.

Applicant's summary and conclusion

Interpretation of results:
other: Not irritating
Conclusions:
The chemical C. I. Pigment Yellow 12 (CAS no: 6358-85-6) was considered as not irritating to the eye of rabbits.
Executive summary:

An eye irritation study of C. I. Pigment Yellow 12 (CAS no: 6358-85-6) was conducted on rabbits to determine the degree of eye irritation according to OECD Guide-line 405 “Acute Eye Irritation/Corrosion”

 

When chemical C. I. Pigment Yellow 12 was instilled into the eyes of each rabbit, no ocular lesions were observed. Hence thechemical C. I. Pigment Yellow 12 (CAS no: 6358-85-6) was considered as not irritating to the eye of rabbits.