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EC number: 269-950-3 | CAS number: 68391-42-4
Study conducted according to OECD guideline 405. Three female New Zealand White rabbits were exposed to test substance for 24 h. After gently pulling the lower lid away from the eye, a volume of 100 µl of pulverized test substance (equivalent to approximately 68 mg) was placed into the conjunctival sac of one eye of each rabbit. The lids were then gently held together for about one second in order to limit loss of the material. 24 h after instillation of the test substance, the treated eye was rinsed with normal saline.
Eye irritation (Draize scoring): signs of cornea (opacity, and area affected), iris (hyperaemia, reaction to light), conjunctivae i.e. conjunctiva of bulbus, lids, and nictitating membrane (erythema, chemosis), and discharge were recorded after 1, 24, 48, 72 h and 7 d. In parallel, the opacity of the aqueous humour (McDonald and Shadduck method) was also assessed for potential epithelial damage.
Effects on conjunctivae in terms of chemosis and redness were noted in rabbits. However, slight reactions of the mucous membranes were fully reversible within 7 d. Test substance was not irritant to rabbit eye.
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