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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
See attached QMRF/QPRF
Principles of method if other than guideline:
Estimation by MPBPVP program, USEPA/Syracuse Research, v1.40 (see attached QMRF and QPRF)
GLP compliance:
no
Type of method:
other: QSAR
Key result
Test no.:
#1
Temp.:
25 °C
Vapour pressure:
0 Pa

A predicted vapour pressure value of 2.7E-9 Pa was determined for the substance. This is an accepted calculation method supported by a limited amount of additional validation.

Conclusions:
A predicted vapour pressure value of 2.7E-9 Pa at 25°C was determined for HMDTMP-H using a valid estimation method. The result is considered to be reliable.

Description of key information

Vapour pressure [(HMDTMP (4-7K)]: <2.7E-9 Pa at 25°C (QSAR)

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
25 °C

Additional information

The vapour pressure of the potassium salt of HMDTMP has been read-across from the parent acid (HMDTMP-H). A predicted vapour pressure of 2.7E-9 Pa at 25°C was obtained for HMDTMP-H using an accepted calculation method (MPBPVP program, USEPA/Syracuse Research, v1.43). This predicted value is read-across to the salt, HMDTMP (4-7K) as <2.7E-9 at 25°C since the vapour pressure of the salt is expected to be lower than that of the parent acid. The result (Fisk 2010) is considered to be reliable and is selected as a key study.

 

The impurities are phosphonate salts that are structurally similar to the main constituent or inorganic salts; all will have negligible vapour pressure.