Registration Dossier
Registration Dossier
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EC number: 946-272-2 | CAS number: -
Endpoint summary
Administrative data
Description of key information
For the endpoint aquatic toxicity two GLP-compliant key studies with copper glucoheptonate were conducted. The short term toxicity to D. magna was studied with an acute immobilisation test according to the OECD Guideline 202. The EC50 (48 h) value was 1.6 mg/L. The toxicity to aquatic algae was investigated with a growth inhibition study on P. subcapitata according to the OECD Guideline 201. The EC50 (72 h) value (referring the growth rate) was 0.94 mg/L. Based on this value the substance is subject to classification and labeling. However, there is evidence that the toxicity of copper strongly depends on the chemical properties of the water. Factors significantly reducing copper toxicity like dissolved organic carbon content (Kramer et al. 2004, De Schampelaere et al. 2004, and 2002), low pH-value, Calcium (De Schamphelaere et al. 2002), Sodium (De Schamphelaere et al. 2004) and the increasing hardness of the water (Lloyd 1961) are not accounted for in the laboratory study. Considering the the followed test method for the toxicity to aquatic algae test and the result of the short term toxicity to D. magna, the test substance is not classified with regard to aqautic toxicity
taking into account the provisions laid down in Council Directive 67/548/EEC and CLP Regulation (EC) No 1272/2008.
Additional information
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