Registration Dossier

Administrative data

Description of key information

No studies were available to assess the skin or eye irritation potential of the registered substance, however, data are available for the structural ananlogue substances trimethoxymethylsilane (CAS: 1185-55-3) and triethoxymethylsilane (CAS: 2031-67-6), respectively.
WoE approach:
CAS: 1185-55-3 and CAS: 2031-67-6 (according to OECD TG 404): not irritating to the skin
CAS: 1185-55-3 and CAS: 2031-67-6 (according or similar to OECD TG 405): not irritating to the eye

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Details on read across justifications can be found in the attached justification in the respective target entry and in the overall justification for grouping of substances attached in IUCLID Section 13.

The available studies for skin and eye irritation with the structural analogue substance trimethoxymethylsilane (CAS 1185-55-3) were conducted in accordance with the appropriate test guidelines and to GLP (Hazelton France, 1992b and Kreiling and Jung, 1991). Trimethoxymethylsilane was found to be not irritating to rabbit skin or eyes, although mild effects were observed.

The available skin irritation study on the structural analogue substance triethoxymethylsilane (CAS 2031-67-6) which was conducted in compliance with GLP and in accordance with OECD TG 404, found the substance to be a transient, mild irritant in rabbits. However, the results obtained in this study were not sufficient for classification as a skin irritant (Hazelton France, 1992b). Furthermore, an eye irritation study on the structural analogue substance triethoxymethylsilane (CAS 2031-67-6) which was not in compliance with GLP, but was equivalent or similar to OECD TG 405, showed that triethoxy(methyl)silane was not irritating to rabbit eyes. Only minor, transient eye irritation was observed following instillation of the test material into the eyes of six rabbits. The Draize score of 0.06 out of 13 indicates that triethoxymethylsilane would not be considered irritating to the eyes of rabbits (Bushy Run Research Center, 1981c). All the studies are in agreement of the lack of skin and eye irritation potential of the structural analogue substances, trimethoxymethylsilane and triethoxymethylsilane. This therefore strengthens the overall assumption that the registered substance, dimethoxydimethylsilane, will not be a skin or eye irritant.


Justification for classification or non-classification

The available data on Irritation / Corrosion of the structural analogue substances, trimethoxymethylsilane and triethoxymethylsilane, respectively, do not meet the criteria for classification according to Regulation (EC) 1272/2008 or Directive 67/548/EEC, and are therefore conclusive but not sufficient for classification of the registered substance.