Registration Dossier
Registration Dossier
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EC number: 203-247-4 | CAS number: 104-88-1
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
There are no sensitisation studies available with 4-Chlorobenzaldehyde. However, data on the position isomer 2-Chlorobenzaldehyde can be used in a read-across approach, as both substances differ only in the position of the chloro-substituent at the benzene ring.
2-Chlorobenzaldehyde has been evaluated as a skin sensitiser in the local lymph node assay with female mice which were treated with 0, 25, 50, and 100% (w/v) of the test item in dimethyl sulphoxide by topical application to the dorsum of each ear lobe for three consecutive days.
In this study stimulation indices (S.I.) of 5.21, 5.62, and 3.31 were determined with the test item at concentrations of 25, 50, and 100 %, respectively. The EC3 value could not be calculated, since all obtained S.I. values were above 3.
Based on the result obtained with 2-Chlorobenzaldehyde, 4-Chlorobenzaldehyde is considered to be sensitising.
Justification for classification or non-classification
Based on the results obtained in the toxicity study with the read across substance 2 -Chlorobenzaldehyde and taking into account the provisions laid down in Council Directive 67/548/EEC and CLP, 4 -Chlorobenzaldehyde is classified as a skin senistizer - R43 and as Skin Sens. Cat 1 (H317), respectively.
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