Registration Dossier

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report Date:
1982

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Rats were whole body exposed in a 10 L glas-chamber for 3-7 hours to vapor , generated by bubbling 200 l/h air through 1000 g of the substance.
The observation period was 14 days.
GLP compliance:
no
Test type:
other: saturation test
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 4-Chlorobenzaldehyde
- Physical state: crystalline
- Analytical purity: technically pure
- Lot/batch No.: 2593

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: Breeder Winkelmann, Borchen, Germany
- Weight at study initiation: 160-200 g
- Housing: Makrolon cages typ III
- Diet ( ad libitum): "Altromin R-Haltungsdiät"
- Water (ad libitum): yes


ENVIRONMENTAL CONDITIONS
- Temperature (°C): yes
- Humidity (%): yes
- Air changes (per hr): yes
- Photoperiod (hrs dark / hrs light): yes

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
>= 3 - <= 7 h
Concentrations:
- no data
No. of animals per sex per dose:
- 5 animals per sex
Control animals:
no
Details on study design:
- The animals were observed for signs of toxicity and mortality over a period of 14 days.
- Necropsy of survivors performed: yes

Results and discussion

Mortality:
No mortality was seen.
Clinical signs:
Irritation of the mucose membranes of the eye and nose and unspecific behavioural disorder was noted in all animals up to 7 hours after exposure.
Body weight:
The weight gain of the 14-day observation period was normal and physiological for male animals.
Female animals of both groups showed a body weight reduction within the first week of the observation period, but in the second week
weight gain was normal.
Gross pathology:
Necropsy revealed slightly distended and grey-red coloured lungs in some animals.

Any other information on results incl. tables

In an acute inhalation toxicity saturation test 5 male and female Wistar rats per group were whole body exposed to 4 -Chlorobenzaldehyde for 3 - 7 hours. Animals then were observed over a period of 14 days. No mortality was seen. Irritation of the mucose membranes of the eye and nose and unspecific behavioural disorder was noted in all animals up to 7 hours after exposure. The weight gain of the 14-day observation period was normal and physiological for male animals. Female animals of both groups showed a body weight reduction within the first week of the observation period, but in the second week weight gain was normal. Necropsy revealed slightly distended and grey-red coloured lungs in some animals.

Applicant's summary and conclusion