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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviewed journal

Data source

Reference
Reference Type:
publication
Title:
A toxicological and dermatological assessment of aryl alkyl alcohols when used as fragrance ingredients.
Author:
D. Belsito, D. Bickers, M. Bruze, P. Calow, M.L. Dagli, A.D. Fryer, H. Greim, Y. Miyachi, J.H. Saurat , I.G. Sipes
Year:
2012
Bibliographic source:
Food and Chemical Toxicology, Vol. 50, Pg. no. S52-S99, 2012.

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
An eye irritation study was conducted to assess the eye irritation potential of chemical 2-Methoxybenzyl alcohol (CAS no: 612-16-8) on three rabbits.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Specific details on test material used for the study:
CAS No: 612-16-8
Name: 2-Methoxybenzyl alcohol
EC No.: 210-296-5
Substance type:Organic
Physical state:Liquid
smiles:O(c1c(cccc1)CO)C
InChI:1S/C8H10O2/c1-10-8-5-3-2-4-7(8)6-9/h2-5,9H,6H2,1H3

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No Data

Test system

Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
0.1 ml
Duration of treatment / exposure:
No data
Observation period (in vivo):
7 days
Duration of post- treatment incubation (in vitro):
no data
Number of animals or in vitro replicates:
3
Details on study design:
No data

Results and discussion

In vitro

Other effects / acceptance of results:
no data

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
7 d
Score:
3
Max. score:
3
Reversibility:
not reversible
Remarks on result:
positive indication of irritation
Irritant / corrosive response data:
definite conjunctival irritation, not clear until day 7

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritating to eyes) based on GHS criteria
Conclusions:
The test material 2-Methoxybenzyl alcohol (CAS no: 612-16-8) was considered to be irritating to the rabbits’ eye.
Executive summary:

An eye irritation study was conducted to assess the eye irritation potential of chemical 2-Methoxybenzyl alcohol (CAS no: 612-16-8) on three rabbits

 

The chemical was installed into the eye of each subjects at a dose of 0.1ml and later observed for ocular lesions.

 

Each treated rabbit showed definite conjunctival irritation which persisted until day 7.

Hence,the chemical2-Methoxybenzyl alcohol (CAS no: 612-16-8) was considered to be irritating to the rabbits’ eye.