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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from Publication.

Data source

Reference
Reference Type:
publication
Title:
Fragrance raw materials monographs: Benzyl alcohol
Author:
D. L. J. Opdyke
Year:
1973
Bibliographic source:
Food and Cosmetics Toxicology, Volume 11, Issue 6, December 1973, Pages 1011-1013.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as metioned below
Principles of method if other than guideline:
Acute oral toxicity study of Benzyl alcohol (100-51-6) in rat..
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzyl alcohol
EC Number:
202-859-9
EC Name:
Benzyl alcohol
Cas Number:
100-51-6
Molecular formula:
C7H8O
IUPAC Name:
Benzenemethanol
Test material form:
liquid
Details on test material:
Name: Benzyl alcohol
InChI: 1S/C7H8O/c8-6-7-4-2-1-3-5-7/h1-5,8H,6H2
Smiles: OCc1ccccc1
- Molecular formula (if other than submission substance):C7H8O
- Molecular weight (if other than submission substance):108.1392 g/mol
- Substance type:Organic
- Physical state:colorless liquid
Specific details on test material used for the study:
Name: Benzyl alcohol
InChI: 1S/C7H8O/c8-6-7-4-2-1-3-5-7/h1-5,8H,6H2
Smiles: OCc1ccccc1
- Molecular formula (if other than submission substance):C7H8O
- Molecular weight (if other than submission substance):108.1392 g/mol
- Substance type:Organic
- Physical state:colorless liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
not specified
Doses:
1230 mg/kg
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 230 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality was observed
Mortality:
50% mortality was observed at 1230 mg/kg bw.
Clinical signs:
other: not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
LD50 was considered to be 1230 mg/kg bw, when rat was treated with Benzyl alcohol (100-51-6) via oral route.
Executive summary:

Acute oral toxicity study of Benzyl alcohol (100-51-6) was conducted in rat at the concentration of 1230 mg/kg. 50% mortality was observed at 1230 mg/kg bw. Therefore, LD50 was considered to be 1230 mg/kg bw, when rat was treated with Benzyl alcohol via oral route.