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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Principles of method if other than guideline:
No information on test method available.
GLP compliance:
no
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Phenethyl cinnamate
EC Number:
203-120-3
EC Name:
Phenethyl cinnamate
Cas Number:
103-53-7
Molecular formula:
C17H16O2
IUPAC Name:
phenethyl cinnamate

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
10 animals in total
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
>= 5 000 mg/kg bw
Mortality:
0/10
Clinical signs:
Diarrhea in 2 animals out of 10 on day 1.
Slight redness in 2 out of 10 animals; slight edema in 1 out of 10.

Applicant's summary and conclusion

Interpretation of results:
other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008
Conclusions:
The test item tested via dermal route had an LD50 greater than 5000 mg/kg bw
Executive summary:

In the current test the acute toxicity via the dermal route of the test item was assessed in rabbits. A single dose of 5000 mg/kg bw of the test substance was applied to 10 animals. No animals died and therefore the LD50 > 5000 mg/kg bw. Slight erythema was observed in 2/10 animals, slight edema in 1/10. Furthermore, 2 rabbits had diarrhea on day 1.