Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-120-3 | CAS number: 103-53-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Principles of method if other than guideline:
- No information on test method available.
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- Phenethyl cinnamate
- EC Number:
- 203-120-3
- EC Name:
- Phenethyl cinnamate
- Cas Number:
- 103-53-7
- Molecular formula:
- C17H16O2
- IUPAC Name:
- phenethyl cinnamate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 animals in total
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- >= 5 000 mg/kg bw
- Mortality:
- 0/10
- Clinical signs:
- Diarrhea in 2 animals out of 10 on day 1.
Slight redness in 2 out of 10 animals; slight edema in 1 out of 10.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008
- Conclusions:
- The test item tested via dermal route had an LD50 greater than 5000 mg/kg bw
- Executive summary:
In the current test the acute toxicity via the dermal route of the test item was assessed in rabbits. A single dose of 5000 mg/kg bw of the test substance was applied to 10 animals. No animals died and therefore the LD50 > 5000 mg/kg bw. Slight erythema was observed in 2/10 animals, slight edema in 1/10. Furthermore, 2 rabbits had diarrhea on day 1.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
