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Physical & Chemical properties

Water solubility

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Description of key information

Under the conditions of the study, the water solubility of the test material was determined to be < 0.05 µg/mL.

Key value for chemical safety assessment

Water solubility:
0.05 µg/L
at the temperature of:
20 °C

Additional information

The water solubilty of the test material was invesigated in a GLP study conducted in accordance to the standardised guideline OECD 105. Preliminary investigations suggested that the water solubility of the test material was very low and when high speed stirring was employed an unbreakable emulsion was formed. Its relative density was less than that of water so an adaptation of the slow stir method detailed in OECD guideline 123 was used. The study was assigned a reliability score of 1 in accordance with the criteria for assessing data quality set forth by Klimisch et al. (1997).

For the main test, three slow stir vessels were charged with double-distilled water (900 mL) and a stirrer bar added. An aliquot of test material (about 5 g) was carefully added to the surface of the water of each vessel, so as not to induce mixing. The vessels were placed on stirrer plates in an incubator controlled at 20 ± 0.5 °C. The stirring rate adjusted, to 200 rpm, such that the vortex of test material was about 0.5 cm deep. Samples of the aqueous portion were taken from the drain tap at 7 day intervals until a constant level of test material in the water was established. The dead volume in the tap (about 5 mL) was run to waste and then an aliquot of about 15 mL taken. This aliquot was allowed to stand for 6 days at 20 ± 0.5 °C, before analysis. An aliquot of the sample was diluted 1:1 with THF to be within the calibration line for Method SMV (PC) 3201220-01V (WAT). For comparison an aliquot of the sample was syringe filtered through a 0.45 µm PTFE filter and analysed as above, this was performed due to the possibility of particulates being present in the supernatant and was used as the definitive water solubility. All the results were below the limit of detection (LOD) and in many cases could not be distinguished from base line noise. The limit of quantitation for the method was 0.05 µg/mL. It was concluded that the water solubility of the test material is < 0.05 µg/mL. There was also visual degradation evidenced by the breaking up of the test material during the test. The temperature was controlled at 20 ± 0.5 °C.

Under the conditions of the study, the water solubility of the test material was determined to be < 0.05 µg/mL.