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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 431 (In Vitro Skin Corrosion: Reconstructed Human Epidermis (RHE) Test Method)
Version / remarks:
Adopted: July 29, 2016
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1-diethylaminopropan-2-ol
EC Number:
224-537-7
EC Name:
1-diethylaminopropan-2-ol
Cas Number:
4402-32-8
Molecular formula:
C7H17NO
IUPAC Name:
1-(diethylamino)propan-2-ol
Test material form:
liquid

In vitro test system

Test system:
human skin model
Source species:
human
Vehicle:
unchanged (no vehicle)
Control samples:
yes, concurrent no treatment
Amount/concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 50µl

NEGATIVE CONTROL
- Amount(s) applied (volume or weight): 50 µl water

POSITIVE CONTROL
- Amount(s) applied (volume or weight): 50 µl
Duration of treatment / exposure:
3-minute and 60-minute exposures were conducted
Number of replicates:
duplicates

Results and discussion

In vitro

Resultsopen allclose all
Irritation / corrosion parameter:
% tissue viability
Remarks:
3-minute exposure
Run / experiment:
1
Value:
14.9
Negative controls validity:
valid
Positive controls validity:
valid
Irritation / corrosion parameter:
% tissue viability
Remarks:
3-minute exposure
Run / experiment:
2
Value:
23.8
Negative controls validity:
valid
Positive controls validity:
valid
Irritation / corrosion parameter:
% tissue viability
Remarks:
3-minute exposure
Run / experiment:
mean
Value:
19.4
Negative controls validity:
valid
Positive controls validity:
valid
Irritation / corrosion parameter:
% tissue viability
Remarks:
60-minutes exposure
Run / experiment:
1
Value:
7.7
Negative controls validity:
valid
Positive controls validity:
valid
Irritation / corrosion parameter:
% tissue viability
Remarks:
60-minutes exposure
Run / experiment:
2
Value:
9.2
Negative controls validity:
valid
Positive controls validity:
valid
Irritation / corrosion parameter:
% tissue viability
Remarks:
60-minutes exposure
Run / experiment:
mean
Value:
8.5
Negative controls validity:
valid
Positive controls validity:
valid

Applicant's summary and conclusion

Interpretation of results:
Category 1A (corrosive) based on GHS criteria
Conclusions:
The ability of 1-Diethylaminopropan-2-ol to induce skin corrosion was investigated by using EpiDerm™SCT (EPI-200).
As a result of the skin corrosion test in the 3-minute and 60-minute exposures, the tissue viabilities treated by the test substance were 19.4% and 8.5%, respectively.
Consequently, it was concluded that 1-Diethylaminopropan-2-ol is "Corrosive" (UN GHS Category 1A) under the present test conditions.