Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 945-962-0 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Respiratory sensitisation
Experimental data on respiratory sensitisation of Flurbiprofen t-butyl ester are not available.
As a results of the profiling of the substance performed by means QSAR Toolbox, structural alerts were not found.
Overall, available data are inconclusive for the classification of the substance.
Skin sensitisation
Experimental data on skin sensitisation of Flurbiprofen t-butyl ester are not available.
QSAR Toolbox has identified one structural alert for the protein binding potency h-CLAT (human cell line activation), this alert is the "Monohaloarenes". By contrast, considering that (i) the ability of substance to react with proteins (Direct Peptide Reactivity Assay (DPRA)) during adverse outcome pathway (AOP) for skin sensitization is considered "non reactive" because one halogen is too weak to take part of SNAr reactions, (ii) structural alerts were not found for the "Protein binding alerts for skin sensitisation (GHS)"/"Protein binding alerts for skin sensitisation (OESIS)" and (iii) Toxtree model confirmed "No skin sensitisation reactivity domains alerts identified"; available data are inconclusive for the classification of the substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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