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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: OECD Guideline 420 EC Directive 92/69/EEC Annex V Test B1 bis OPPTS 870.1100
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test animals

Species:
other: Sprague-Dawley rats

Administration / exposure

Vehicle:
other: SNEA administered as supplied.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 50 mg/kg bw
Mortality:
Male: 50 mg/kg bw; Number of animals: 5; Number of deaths: 0Female: 50 mg/kg bw; Number of animals: 5; Number of deaths: 0Female: 500 mg/kg bw; Number of animals: 1; Number of deaths: 1
Clinical signs:
Signs of toxicity related to dose levels:In the dose ranging study, there was one death at 500 mg/kgdose level. Prior to death, major clinical signs includedconvulsions, laboured breathing, prostration and theappearance of a white substance at the mouth. Theanimal was found dead within 25 min of dosing.As a result of the mortality and clinical observations, thedefinitive test was conducted at 50 mg/kg. No prematuredecendants resulted at this dose level and there were noadverse clinical signs noted during the study.
Gross pathology:
Effects on organs:Necropsy was only conducted on animals in the definitivetest. No abnormalities were noted.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated informationCriteria used for interpretation of results: EU