Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 237-185-4 | CAS number: 13680-35-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- QSAR-calculation by EPIWIN based on the experimental log POW value of 4.40
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSARs: Chapter R.6. QSARs and grouping of chemicals
- GLP compliance:
- no
- Specific details on test material used for the study:
- TEST MATERIAL
- Substance identification/name in the report: LZ 596
- Molecular formula: C21H30N2
- Smiles: Nc(c(cc(c1)Cc(cc(c(N)c2CC)CC)c2)CC)c1CC - Radiolabelling:
- no
- Justification for method:
- minimised test method used to support BCF estimates based on Kow
- Key result
- Temp.:
- ca. 25 °C
- Type:
- BCF
- Value:
- 372 L/kg
- Basis:
- other: calculation based on experimental Log Pow
- Key result
- Temp.:
- ca. 25 °C
- Type:
- BAF
- Value:
- 29.8 L/kg
- Basis:
- other: calculation based on experimental Log Pow
- Validity criteria fulfilled:
- yes
- Conclusions:
- A BCF of 372 L/kg wet-wt (log BCF 2.57) was obtained by QSAR-calculation.
- Executive summary:
The bioconcentration factor was calculated based on the experimental Log Pow of 4.4 applying the EPIWIN-program (BCFBAF V3.01). A BCF of 372 L/kg wet-wt (log BCF 2.57) was obtained. Based on this result, the test item does not have bioaccumulating properties.
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- QSAR-calculation by EPIWIN applying the Arnot-Gobas method
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSARs: Chapter R.6. QSARs and grouping of chemicals
- GLP compliance:
- no
- Specific details on test material used for the study:
- TEST MATERIAL
- Substance identification/name in the report: LZ 596
- Molecular formula: C21H30N2
- Smiles: Nc(c(cc(c1)Cc(cc(c(N)c2CC)CC)c2)CC)c1CC - Radiolabelling:
- no
- Key result
- Temp.:
- ca. 25 °C
- Type:
- BCF
- Value:
- 2 469 L/kg
- Basis:
- other: calculation based on experimental Log Pow
- Key result
- Temp.:
- ca. 25 °C
- Type:
- BAF
- Value:
- 10 370 L/kg
- Basis:
- other: calculation acc. Arnot-Gobas method
- Details on results:
- The BCF was predicted assuming a biotransformation rate of zero.
- Validity criteria fulfilled:
- yes
- Conclusions:
- A BCF (upper trophic) of 2469 L/kg wet-wt (log BCF 3.393) was obtained by QSAR-calculation.
- Executive summary:
The bioconcentration factor was calculated according to the Arnot-Gobas method applying the EPIWIN-program (BCFBAF V3.01). A BCF (upper trophic) of 2469 L/kg wet-wt (log BCF 3.393) was obtained by QSAR-calculation (biotransformation assumed as zero).
Thus, the substance is “Potentially P or vP”.
- Endpoint:
- bioaccumulation in aquatic species: fish
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because direct and indirect exposure of the aquatic compartment to the substance is unlikely
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
Based on the intended uses of the test ite, direct and indirect exposure of the aquatic compartment is unlikely. A calculation of the BCF by the EPIWIN-software showed an estlmated Log BCF of 2.510, corresponding to a BCF of 371.6 L/kg wet-wt.
Referenceopen allclose all
Description of key information
Study was waived. Based on the intended uses of the test item, direct and indirect exposure of the aquatic compartment is unlikely. A calculation of the BCF by the EPIWIN-software showed the following estimated figures:
- a Log BCF of 2.510, corresponding to a BCF of 371.6 L/kg wet-wt, based on the experimental Log Pow of 4.4
- a Log BCF of 3.393, corresponding to a BCF of 2469 L/kg wet-wt, based on Arnot-Gobas method (biotransformation assumed as zero)
Key value for chemical safety assessment
- BCF (aquatic species):
- 2 469 L/kg ww
Additional information
Source: Calculation & expert assessment
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
