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EC number: 237-185-4 | CAS number: 13680-35-8
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November - December 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Specific details on test material used for the study:
- TEST MATERIAL
- Substance identification/name in the report: LZ 596
- Molecular formula: C21H30N2
- Batch no.: 1229
- Analysis date: August 12, 2014
- Date of production: August 11, 2014
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage conditions: Controlled room temperature (15-25 ºC, below 70 RH%), protected from light and humidity.
- Stability under test conditions: stable for min. 3 years from manufacturing date
- Expiry date: August 10, 2017
- Safety precautions: Routine safety precautions (lab coat, gloves, safety glasses, face mask) for unknown materials were applied to assure personnel health and safety. - Key result
- Water solubility:
- 0.44 mg/L
- Conc. based on:
- test mat. (total fraction)
- Incubation duration:
- 74 h
- Temp.:
- 20 °C
- pH:
- 6.8 - 7.1
- Details on results:
- The following concentrations were measured in the solutions saturated by the 24 hours shake-flask experiment: 1.9; 1.8 and 1.5 mg/L. The mean value is 1.7 mg/L.
Based on this value the column elution method was applied in the course of the main study. - Conclusions:
- The water solubility of the test item was determined to be 0.44 mg/L at 20°C at a pH-value of 6.8-7.1.
- Executive summary:
The study was conducted according to EC method A.6, using the column-elution method. After the equilibrium was reached measured pH values varied between 6.8 and 7.1. In conclusion, the water solubility of the test item was determined to be 0.44 mg/L at 20°C.
Reference
Description of key information
The study was conducted according to EC method A.6, using the column-elution method. After the equilibrium was reached measured pH values varied between 6.8 and 7.1.In conclusion, the water solubility of the test item was determined to be 0.44 mg/L at 20°C.
Key value for chemical safety assessment
- Water solubility:
- 0.44 mg/L
- at the temperature of:
- 20 °C
Additional information
Source: GLP-report
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