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Diss Factsheets

Physical & Chemical properties

Water solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
November - December 2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
column elution method
Specific details on test material used for the study:
TEST MATERIAL
- Substance identification/name in the report: LZ 596
- Molecular formula: C21H30N2
- Batch no.: 1229
- Analysis date: August 12, 2014
- Date of production: August 11, 2014

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage conditions: Controlled room temperature (15-25 ºC, below 70 RH%), protected from light and humidity.
- Stability under test conditions: stable for min. 3 years from manufacturing date
- Expiry date: August 10, 2017
- Safety precautions: Routine safety precautions (lab coat, gloves, safety glasses, face mask) for unknown materials were applied to assure personnel health and safety.
Key result
Water solubility:
0.44 mg/L
Conc. based on:
test mat. (total fraction)
Incubation duration:
74 h
Temp.:
20 °C
pH:
6.8 - 7.1
Details on results:
The following concentrations were measured in the solutions saturated by the 24 hours shake-flask experiment: 1.9; 1.8 and 1.5 mg/L. The mean value is 1.7 mg/L.
Based on this value the column elution method was applied in the course of the main study.
Conclusions:
The water solubility of the test item was determined to be 0.44 mg/L at 20°C at a pH-value of 6.8-7.1.
Executive summary:

The study was conducted according to EC method A.6, using the column-elution method. After the equilibrium was reached measured pH values varied between 6.8 and 7.1. In conclusion, the water solubility of the test item was determined to be 0.44 mg/L at 20°C.

Description of key information

The study was conducted according to EC method A.6, using the column-elution method. After the equilibrium was reached measured pH values varied between 6.8 and 7.1.In conclusion, the water solubility of the test item was determined to be 0.44 mg/L at 20°C.

Key value for chemical safety assessment

Water solubility:
0.44 mg/L
at the temperature of:
20 °C

Additional information

Source: GLP-report