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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
significant methodological deficiencies

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report Date:
1973

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
other: ChR-CD
Sex:
male

Administration / exposure

Route of administration:
inhalation: gas
Type of inhalation exposure:
whole body
Vehicle:
oxygen
Analytical verification of test atmosphere concentrations:
yes
Remarks:
Atmospheric concentration of oxygen was measured periodically with a MSA oxygen meter to maintain an O2 level of 20% (vol/vol)
Duration of exposure:
ca. 2 h
Remarks on duration:
intended exposure of 4 hours
Concentrations:
800000 ppm (80%)
No. of animals per sex per dose:
6 male rats
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LC100
Effect level:
ca. 800 000 ppm
Based on:
test mat.
Exp. duration:
2 h
Mortality:
Mortality ratio: 6/6
Clinical signs:
During exposure: Face-pawing, grooming, salivation, labored respiration, lacrimation, hyperemia, tremors, convulsions.
These signs were indicative of respiratory irritation and central nervous system effects.
Gross pathology:
Not performed

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
Octafluorocyclobutane was lethal to a group of 6 rats after two hours of an intended four-hour exposure to 80% (v/v). The clinical signs observed during exposure were indicative of respiratory irritation and central nervous system effects.