Registration Dossier

Administrative data

Endpoint:
dermal absorption, other
Remarks:
predicted dermal absorption
Type of information:
(Q)SAR
Remarks:
prediction by EPIsuite
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Application of the threshold of toxicological concern (TTC) to the safety evaluation of cosmetic ingredients
Author:
Kroes, Renwick, Feron, Galli, Gibney, Greim, Guy, Lhuguenot, van de Sandt
Year:
2007
Bibliographic source:
Food and Chemical Toxicology, 45 (2007), 2533-2562
Reference Type:
secondary source
Title:
ChemIDPlus: Tetrafluoromethane
Year:
2017
Bibliographic source:
TOXNET, ChemIDplus database

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Prediction by EPIsuite
GLP compliance:
not specified

Results and discussion

Percutaneous absorption
Key result
Parameter:
percentage
Absorption:
ca. 10 %

Applicant's summary and conclusion

Conclusions:
Based on the physico-chemical properties of tetrafluoromethane (MW = 88.003 g/mol, log Kow = 1.18, water solubility = 18.8 mg/L), skin absorption is expected to be 10%.