Tetrahydrocyclopenta[c]pyrrole-1,3(2H,3aH)-dione

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2011

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

In the preliminary test the water solubility of the test substance was ≥ 10-2 g/l. Therefore, the flask
method was chosen for the main study.
Main study
Three aliquots between 11639 and 11644 mg of the test substance were weighed into glass vessels.
To each vessel, 25 ml double distilled water was added. The vessels were placed on a magnetic
852 IMIDE BRUTE NOTOX Project 496952
Final report - Page 34 -
stirring device in a climate room at 19.9  0.6°C where the content of each vessel was stirred for 24,
48 or 72 hours. As the blank, 25 ml double distilled water was stirred for 72 hours.
After the stirring period, the water phases were centrifuged for 5 minutes at 6500 g and 20°C. In order
to remove undissolved test substance particles floating on the surface, the upper layers were removed
by suction using a water aspirator pump. The aqueous phases were pipetted off and centrifuged a
second and third time (same conditions). Accurately weighed volumes of 50 μl of the aqueous phases
were diluted with 10/90 (v/v) methanol/water in volumetric flasks of 5 ml. The solutions were further
diluted with 10/90 (v/v) methanol/water to obtain concentrations within the calibration range.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2011

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

Tetrahydrocyclopenta[c]pyrrole-1,3(2H,3aH)-dione

EC Number:

227-285-6

EC Name:

Tetrahydrocyclopenta[c]pyrrole-1,3(2H,3aH)-dione

Cas Number:

5763-44-0

Molecular formula:

C7H9NO2

IUPAC Name:

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

Test material form:

solid: flakes

Results and discussion

Water solubility

Key result

Water solubility:

ca. 199 g/L

Conc. based on:

test mat. (total fraction)

Incubation duration:

ca. 72 h

Temp.:

20 °C

pH:

> 7.1 - < 7.2

Applicant's summary and conclusion

Conclusions:

The water solubility of the test substance at 20°C was 199 g/l.
The pH of the aqueous samples was 7.1 – 7.2.