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EC number: 207-892-2 | CAS number: 499-80-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data from handbook or collection of data
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Safety Assessment of Trimellitic Anhydride Copolymers as Used in Cosmetics
- Author:
- cosmetic ingredient review expert panel
- Year:
- 2 016
- Bibliographic source:
- cosmetic ingredient review expert panel; November 14, 2016
- Reference Type:
- secondary source
- Title:
- IUCLID Dataset for CAS 121-91-5
- Author:
- EUROPEAN COMMISSION – European Chemicals Bureau
- Year:
- 2 000
- Bibliographic source:
- IUCLID Dataset; EUROPEAN COMMISSION – European Chemicals Bureau; 18–FEB–2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- A Buehler Test was conducted on ten male guinea pigs for chemical isophthalic acid (CAS No: 121-91-5) to assess its skin sensitization potential.
- GLP compliance:
- not specified
- Type of study:
- Buehler test
- Justification for non-LLNA method:
- not specified
Test material
- Reference substance name:
- Isophthalic acid
- EC Number:
- 204-506-4
- EC Name:
- Isophthalic acid
- Cas Number:
- 121-91-5
- Molecular formula:
- C8H6O4
- IUPAC Name:
- 1,3-benzenedicarboxylic acid
- Test material form:
- solid
- Details on test material:
- Name of the test chemical: Isophthtalic acid
Molecular Formula:C8H6O4
Molecular Weight: 166.1314 g/mol
InChI: 1S/C8H6O4/c9-7(10)5-2-1-3-6(4-5)8(11)12/h1-4H,(H,9,10)(H,11,12)
Substance Type: Organic
Physical State: Solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Isophthalic acid
- Molecular formula: C8H6O4
- Molecular weight: 166.1314
- Substance type: organic
- Physical state: solid
-Smiles: c1cc(cc(c1)C(=O)O)C(=O)O
-InChI: 1S/C8H6O4/c9-7(10)5-2-1-3-6(4-5)8(11)12/h1-4H,(H,9,10)(H,11,12)
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- male
- Details on test animals and environmental conditions:
- No data available
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, occlusive
- Vehicle:
- DMSO
- Concentration / amount:
- 30% (0.3mL)
- Day(s)/duration:
- 3 weeks
- Adequacy of induction:
- not specified
Challenge
- No.:
- #1
- Route:
- epicutaneous, occlusive
- Vehicle:
- DMSO
- Concentration / amount:
- 30% (0.3mL)
- Day(s)/duration:
- 48 hours
- Adequacy of challenge:
- not specified
- No. of animals per dose:
- 30 (10 guinea pigs/Group)
- Details on study design:
- MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 3
- Exposure period: no data
- Test groups: 10 guinea pigs
- Control group: 10 guinea pigs
- Site: shaved backs
- Frequency of applications: once a week
- Duration: 3 weeks
- Concentrations: 30% (0.3mL)
B. CHALLENGE EXPOSURE
- No. of exposures: 1
- Day(s) of challenge: after 2 weeks
- Exposure period: 24 hours
- Test groups: 10 guinea pigs
- Control group: 10 guinea pigs
- Site: no data
- Concentrations: 30% (0.3mL)
- Evaluation (hr after challenge): 24 hours and 48 hours - Challenge controls:
- The sham control guinea pigs each received a challenge dose of 0.3 ml of the 30% test article/DMSO solution; the vehicle control guinea pigs each received a challenge dose of 0.3 ml of a 70% (w/w) aqueous DMSO solution.
- Positive control substance(s):
- not specified
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 30% (0.3mL)
- No. with + reactions:
- 1
- Total no. in group:
- 10
- Clinical observations:
- Positive erythema reactions (i.e., a score >= 2) were observed in only one test article–treated guinea pig, compared to no vehicle or sham control guinea pigs during the challenge phase.
- Remarks on result:
- no indication of skin sensitisation
In vivo (LLNA)
- Cellular proliferation data / Observations:
- Positive erythema reactions (i.e., a score >= 2) were observed in only one test article–treated guinea pig, compared to no vehicle or sham control guinea pigs during the challenge phase.
Any other information on results incl. tables
The primary effect of treatment (treated vs. control) and the secondary effect of time of scoring (24 hr vs. 48 hr) were not statistically significant. These findings indicate that dermal sensitization did not result from repeated dermal application of Isophthalic acid.
Applicant's summary and conclusion
- Interpretation of results:
- other: not sensitizing
- Conclusions:
- The test material isophthalic acid (CAS No: 121-91-5) was considered as not sensitizing to the skin of guinea pigs.
- Executive summary:
A Buehler Test was conducted on ten male guinea pigs for chemicalisophthalic acid (CAS No:121-91-5) to assess its skin sensitization potential.
Isophthalic acid was applied once a week at a dose of 0.3ml of a 30% (w/w) solution in dimethylsulfoxide (DMSO) to the shaved backs of ten male guinea pigs during an induction period of three weeks. Another group of 10 male guinea pigs served as a vehicle control and was similarly dosed with 0.3ml of undiluted DMSO. A third group of ten sham control guinea pigs was handled in the same manner, but was not treated with test article or vehicle. Two weeks following application of the third induction dose, the treated andsham control guinea pigs each received a challenge dose of 0.3 ml of the 30% test article/DMSO solution; the vehicle control guinea pigs each received a challenge dose of 0.3 ml of a 70% (w/w) aqueous DMSO solution. All guinea pigs were scored for erythema approximately 24 and 48 hours following application of the first induction dose and the challenge dose.
Positive erythema reactions (i.e., a score >= 2) were observed in only one test article–treated guinea pig, compared to no vehicle or sham control guinea pigs during the challenge phase.
Since no sensitization reactions were observed in majority of treated animals, the chemical isophthalicacid (CAS No:121-91-5) was considered as not sensitizing to the skin of guinea pigs.
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