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EC number: 240-979-3 | CAS number: 16921-30-5
Table: Individual scores for each time point
N: Local areas of necrosis where the sample has entered abrasions on the epidermis
In a US Federal Register Patch Test (1973), the skin irritant potential of sodium hexachloroplatinate was assessed in six female New Zealand White rabbits. The test material (0.5 g) was applied (occluded) to the shaved abraded and intact skin for 24 hr.The sites were assessed for evidence of erythema (and eschar) formation and oedema formation immediately upon removal of the patch, and again 48 hr later.
The intact skin sites displayed no evidence of erythema/oedema at either time point. Three abraded sites showed evidence of possible necrosis associated with the abrasions in the skin.A Primary Irritation Score of 0.5 (out of 8) was obtained. The study authors classified sodium hexachloroplatinate as a mild skin irritant in this test system
This study suffered from a number of significant deviations from those given in the current OECD guidelines, including use of abraded skin, no moistening of test substance (a powder) to ensure good skin contact, a longer exposure period and failure to wash off any residual test material after removal of patch, observation period was insufficient to assess reversibility of effects, and skin was only examined on 2 occasions, at 0 and 48 hrs, rather than at 1, 24, 48 and 72 hrs, after patch removal. However, certain of these deviations are likely to increase the possibility of an irritant reaction.
Based on the results of this study, no classification for skin irritation is required under EUCLP criteria (EC 1272/2008).
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