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Diss Factsheets
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EC number: 817-668-1 | CAS number: 667899-24-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 100
- Absorption rate - inhalation (%):
- 100
Additional information
No published data could be identified on the toxicokinetics of the substance. However, as per REACH guidance document R7. C (June 2017), information on absorption, distribution, metabolism and excretion may be deduced from the physico-chemical properties including:
- Water solubility
- Partition coefficient
- Vapour pressure
- Molecular weight
The substance is a UVCB, with the majority of the constituents having a molecular weight >500. It is a liquid with a tested water solubility of 0.69 μg/L. Volatility was determined to be very low (1.6E-8 Pa at 20°C) and the estimated partition coefficient of the substance is 12.04.
Taking into account the log Kow (12.04) and the water solubility (0.69 μg/L), bioaccumulation of the substance is likely to be low. According to ECHA Guidance for PBT assessment R.11, the aquatic BCF of a substance is probably lower than 2000 if the calculated log Kow is higher than 10. This is supported by the indication of poor bioavailability following oral absorption (as can be seen below) and therefore, less tendency to bioaccumulate.
Oral and gastrointestinal (GI) absorption: Given the very low water solubility and high partition coefficient of the substance, it is unlikely to be soluble in the GI fluid. However, due to the high log Kow some extent of micellar solubilisation might occur. Therefore, the substance may be considered to be partially absorbed through the GI system leading to low oral bioavailability. This is supported by the absence of any sign of systemic toxicity in acute or repeated dose studies. However, in the absence of actual data, the default value of 50% has been considered for oral absorption.
Dermal absorption:
Similarly, for dermal route, the high molecular weight along with very low water solubility indicates poor absorption. Also, due to the high log Kow the rate of transfer between the stratum corneum and the epidermis is likely to be low. However, in absence of actual data, a default 100% absorption is assumed.
Inhalation absorption: The high log Kow of the substance along with poor water solubility indicates that some extent of micellar solubilisation might occur upon inhalation exposure. Therefore, similar to oral absorption, a low bioavailability of the substance might be assumed through inhalation route. In the absence of actual data,a default value of 100% has been considered for inhalation absorption.
Metabolism: QSAR profiling of the constituents present at greater than 5% revealed aliphatic hydroxylation or ester hydrolysis as the initial metabolic step.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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