Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 214-987-2 | CAS number: 1241-94-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The key study was a human two application patch test, in which 100 males and 100 female subjects were exposed twice (15 days rest period) for 48 hours on the upper arm using an occluded patch (impregnated paper). Skin reactions were scored at 0, 24 and 48 hours after removal of the patch to determine the sensitasing potential of the test substance.
30 out of 200 subjects showed positive skin reactions at 1 of the 3 readings after induction. At the challenge phase, 29 out of 200 subjects showed a positive skin reaction at 1 of the 3 readings. Only 1 human subject showed an additional positive skin reaction at the challenge readings, while in 2 other subjects the reaction disappeared.
Under the conditions of this study, it was not possible to conclude on the sensitising potential of Santicizer 141, as the substance can be considered rather irritating than sensitising.
Migrated from Short description of key information:
Human (2-application) patch test: not sensitising
Justification for classification or non-classification
Based on the available data, no conclusion can be drawn considering the classification for skin sensitisation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
