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EC number: 214-987-2
CAS number: 1241-94-7
No toxicokinetic studies are available. The available
toxicity studies provide no or little information. Therefore the
assessment is primarily based on physicochemical properties, supported
by some toxicological information.
Physical and chemical properties
The physical/chemical properties that are of importance
to assess the toxicokinetics behaviour of IDDPP are:
2EHDPP is highly lipophilic (Based on log Kow) and
therefore oral/GI-absorption by passive diffusion is expected to be
limited. If any absorption occurs, micellular solubilisation will be the
major mechanism for absorption, also based on the low water solubility
and low molecular weight. In a Range Finding Acute Oral Toxicity study
at autopsy there were haemorrhagic
areas of the liver, lungs, and kidneys, and intestinal inflammation
found (Birch, Melvin D., 1969). This indicates that oral absorption has
occurred. Acute toxicity tests give little additional information.
The same absorption patterns are considered to be
applicable for respiratory absorption, although exposure via this route
is unlikely based on the low vapour pressure. Based on acute inhalation
toxicity study an LC50 of 2.1 mg/L (6hr) has established, indicating
that 2EHDPP is classified as harmful by inhalation. This confirms that
respiratory absorption of the substance has occurred and might be the
main exposure route.
Because of its highly lipophilic character the dermal
penetration of 2EHDPP into the stratum corneum will be high. However,
because of its very low water solubility the rate of penetration from
the stratum corneum into the epidermis is likely to be low and therefore
dermal absorption is considered to be low.
Distribution, metabolism and elimination
There is no information about the distribution,
metabolism, excretion, bioavailability and accumulation of 2EHDPP. Based
on the physical chemical properties the substance is likely to be
distributed into cells and to a lower extent into the extracellular
spaces. Since its highly lipophilic character it is anticipated that it
tends to be accumulated in adipose tissues and in lipophilic layers like
No specific target organ has been identified. The effects
of repeated exposure to 2EHDPP are investigated in two studies. Both
studies report hypertrophy of the liver as key finding. Brain and
adrenal weight was significantly increased for the high dose males,
showing a dose-related response. Kidney, testes and caecum (empty)
weight was significantly increased for the mid and high dose group, also
indicating a dose-related response. This was also seen for the liver,
but here all treated males had a significantly increased weight.
2EHDPP can be absorbed after oral exposure, but
respiratory exposure might be the main exposure route. The amount of
absorption cannot be predicted. Dermal absorption is considered to be
very low. No information is available about the distribution, metabolism
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