Registration Dossier

Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Data source

Reference
Reference Type:
other: QSAR
Title:
Toxtree (Estimation of Toxic Hazard - a Decision Tree Approach) v. 2.6.6 Software for estimation of toxic hazard by applying a decision tree approach Ideaconsult Ltd
Author:
Ideaconsult
Year:
2016
Bibliographic source:
http://toxtree.sourceforge.net

Materials and methods

Principles of method if other than guideline:
QSAR method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid
Specific details on test material used for the study:
The model was run twice using the following two SMILES code structural formulas that are the substructures that comprise the substance known by this EC number:
[W]1(=O)(=O)O[W](=O)(=O)O[W](=O)(=O)O1
[Si](O)(O)(O)O

Test animals

Species:
other: rodent

Results and discussion

Test resultsopen allclose all
Genotoxicity:
negative
Remarks on result:
other: no alerts for structure [W]1(=O)(=O)O[W](=O)(=O)O[W](=O)(=O)O1
Genotoxicity:
negative
Remarks on result:
other: no alerts for structure [Si](O)(O)(O)O

Applicant's summary and conclusion

Executive summary:

A valid QSAR model based on the Toxtree ISS rulebase of alerts for the in vitro mouse micronucleus assay predicted that

the two substructures that comprise the substance produced no alerts for mutagenicity.