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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Aug. 1981
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report date:
1981

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Method: standard
GLP compliance:
no
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Anthracene
EC Number:
204-371-1
EC Name:
Anthracene
Cas Number:
120-12-7
Molecular formula:
C14H10
IUPAC Name:
anthracene
Details on test material:
purity: 'Anthrazen reinst'
Product No. 110.147

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Dr. A. Ivanovas, Kisslegg/Germany
- Age at study initiation:
- Weight at study initiation: 220 - 245 (m); 210 - 250 (f)
- Fasting period before study: approx. 16 h, new feed 4 h post-application
- Housing: single
- Diet: ad libitum
- Water: ad libitum


ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +-1
- Photoperiod (hrs dark / hrs light): 12 / 12

Administration / exposure

Type of coverage:
occlusive
Vehicle:
polyethylene glycol
Details on dermal exposure:
TEST SITE
- Area of exposure: 5 x 7.5 cm
- skin shaved
- Type of wrap if used: aluminum foil covered with adhesive tape round the trunk


REMOVAL OF TEST SUBSTANCE
- Washing (if done): luke-warm water
- Time after start of exposure: 24 h


TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1320 mg in 3.3 mL PEG/kg bw (maximum volume technically applicable)
- concentration in vehicle: approx. 25 % (w/v) (maximum amount technically applicable)
- For solids, paste formed: yes


VEHICLE
- Amount(s) applied (volume or weight with unit): 3.3 mL/kg bw
Duration of exposure:
24 h
Doses:
1320 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
yes, concurrent vehicle
Details on study design:
- Duration of observation period following administration: 14 days
Statistics:
not applicable

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
> 1 320 mg/kg bw
Mortality:
none
Clinical signs:
other: none, no systemic effects
Gross pathology:
no particular findings
Other findings:
no local effects

Applicant's summary and conclusion