Registration Dossier
Registration Dossier
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EC number: 260-690-6 | CAS number: 57352-34-8
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from Publication
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Safety Assessment of Xylene Sulfonic Acid, Toluene Sulfonic Acid, and Alkyl Aryl Sulfonate Hydrotropes as Used in Cosmetics
- Author:
- Bergfeld, Wilma F., Donald V. Belsito, Curtis D. Klaassen, Ronald Hill, Daniel Liebler, James G. Marks Jr, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, and F. Alan Andersen.
- Year:
- 2 011
- Bibliographic source:
- International Journal of Toxicology, 30, no. 6_suppl (2011): 270S-283S
- Reference Type:
- secondary source
- Title:
- Hydrotropes
- Author:
- United Nations Environmental Programme (UNEP)
- Year:
- 2 005
- Bibliographic source:
- HYDROTROPES, United Nations Environmental Programme (UNEP), 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as metioned below
- Principles of method if other than guideline:
- Acute inhalation toxicity study for Sodium toluenesulphonate (12068-03-0) in rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- sodium 4-methylbenzenesulfonate
- Cas Number:
- 12068-03-0
- Molecular formula:
- C7H7O3S.Na
- IUPAC Name:
- sodium 4-methylbenzenesulfonate
- Details on test material:
- Name - Sodium toluenesulphonate
InChI: 1S/C7H8O3S.Na/c1-6-2-4-7(5-3-6)11(8,9)10;/h2-5H,1H3,(H,8,9,10); /q;+1/p-1
Smiles - S(c1ccc(C)cc1)(=O)(=O)[O-].[Na+]
- Molecular formula (if other than submission substance):C7H8O3S.Na
- Molecular weight (if other than submission substance):194.185 g/mole
- Substance type:Organic
- Physical state:powdered
Constituent 1
- Specific details on test material used for the study:
- Name - Sodium toluenesulphonate
InChI: 1S/C7H8O3S.Na/c1-6-2-4-7(5-3-6)11(8,9)10;/h2-5H,1H3,(H,8,9,10); /q;+1/p-1
Smiles - S(c1ccc(C)cc1)(=O)(=O)[O-].[Na+]
- Molecular formula (if other than submission substance):C7H8O3S.Na
- Molecular weight (if other than submission substance):194.185 g/mole
- Substance type:Organic
- Physical state:powdered
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remark on MMAD/GSD:
- not specified
- Details on inhalation exposure:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Remarks on duration:
- not specified
- Concentrations:
- 557000 mg/m3
- No. of animals per sex per dose:
- Total = 10 (5 males, 5 females)
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 557 000 mg/m³ air
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed
- Mortality:
- No mortality was observed at 557000 mg/m3
- Clinical signs:
- other: not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The acute inhalation toxicity dose (LC50) in 10 Wistar male/female rat by using Sodium toluenesulphonate (12068-03-0) was considered to be >557000 mg/m3.
- Executive summary:
The acute inhalation toxicity study was conducted by using Sodium toluenesulphonate (12068-03-0) in 10 Wistar male/female rat at the concentration of557000mg/m3. No mortality was observed at 557000 mg/m3.Therefore, LC50 was considered to be >557000 mg/m3, when Wistar male/female rat was treated with Sodium toluenesulphonate by inhalation.
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