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EC number: 500-239-5 | CAS number: 68937-90-6
The results show no measurable penetration of the C18:0 soap through rat skin up to 24 h after application, but 0.2 µg/cm² of the C16:0 soap had penetrated at 24 h. Some 7.5 µg of the C10:0, C12:0 and C14:0 soaps had penetrated per cm² at 24 h but the results were not significantly different for the three soaps. For the three soaps which penetrated the skin there was a lag time of 1 h before any measurable penetration occurred, but after this the rate of penetration steadily increased. At the
end of the experiment,i .e. 24 h after application, between 60 and 70% of the applied [14C] soaps were rinsed from the skin and 30-40% was associated with the skin.
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