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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From August 07 to 12, 2009
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
The study was conducted according to an internationally recognised method, and under GLP. No deviation was reported. Test substance is adequately specified with purity. Therefore full validation applies.
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
March 23, 2006
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
Regulation (EC) No. 440/2008
Deviations:
no
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. certificate)
Remarks:
Swiss GLP compliance programme (inspected on November 5 to 9 and 26 to 30, 2007 / signed on November 12, 2008)
Type of method:
gas saturation method
Specific details on test material used for the study:
Storage condition of test material: In the refrigerator at about 5 °C, in the dark, under Nitrogen
Key result
Temp.:
25 °C
Vapour pressure:
0.178 Pa

The experimental results lead to the conclusion that the vapour pressure of the test item is:

1.4 x 10-2 Pa at 5 °C

4.8 x 10-2 Pa at 15 °C

1.9 x 10-1 Pa at 25 °C

Calculation of the vapour pressure of test item at 25 °C by interpolation based upon the simplified Clausius-Clapeyron equation resulted in a vapour pressure of 1.8 x 10-1 Pa.

 

 

The trapping efficiency of the test item in the first cooling trap was very good. Between 99.7% and 100% of the test item was trapped in the first cooling trap.

 

Table 4.6/1: Data of the vapour pressure curve for test item

T [°C]

1/T [Kelvin]

ln Pvp

5

0.00359

-4.31

0.00359

-4.26

0.00359

-4.24

15

0.00347

-2.96

0.00347

-3.24

0.00347

-2.96

25

0.00335

-1.67

0.00335

-1.70

0.00335

-1.61

 

The tabulated results represent rounded-off values obtained by calculations based on the exact

raw data.

Y = b · x + a with Y = ln (Pvp mean in Pa)

x = 1/T (Kelvin)

b = -10744.86 (slope)

a = 34.31 (y-axis intercept)

r2 = 0.991389

Calculated vapor pressure of test item at 25 °C: 1.78 x 10-1 Pa

See the attached document for figure "Vapour Pressure Curve of test item"

Conclusions:
Low volatility (based on volatility bands criteria for occupational exposure (Chesar / ECETOC TRA), << 500 Pa).
Executive summary:

The vapour pressure of the test substance was measured under GLP according to OECD 104 / EU A4 guideline, gas saturation method. Determinations were conducted at 5, 15 and 25 °C, with three flow rates per temperature. Mass of evaporated test item was quantified by HPLC. Vapour pressure at 25 °C was interpolated from the regression.

The vapour pressure of test substance at 25 °C was interpolated from the vapour pressure curve and was calculated to be 1.78 x 10-1 Pa.

Description of key information

Low volatility.

Key value for chemical safety assessment

Vapour pressure:
0.178 Pa
at the temperature of:
25 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. Therefore, it is considered as a key study, and the result is retained as key data.