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Physical & Chemical properties

Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From December 1 to 12, 2008
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
The study was conducted according to an internationally recognised method, and under GLP. The substance is considered to be adequately characterised with its purity. Validation applies, with minor restrictions due to heating rate.
Qualifier:
according to
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Version / remarks:
1995
Deviations:
yes
Remarks:
heating rate
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Version / remarks:
2008
Deviations:
yes
Remarks:
heating rate
Qualifier:
according to
Guideline:
other: DIN 53736: Method for the Determination of Melting Point
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. certificate)
Remarks:
Swiss GLP compliance programme (inspected on November 15 and 16, 2006 / signed on March 29, 2007)
Type of method:
capillary method
Specific details on test material used for the study:
Storage condition of test material: Refrigerator (between 0 and 10 °C under nitrogen)
Key result
Melting / freezing pt.:
35 °C
Atm. press.:
96.7 kPa

Preliminary test: 307.6 K (34.6 °C) at 96.7 kPa

Determination 1: 307.9 K (34.9 °C) at 96.7 kPa 

Determination 2: 307.8 K( 34.8 °C) at 96.7 kPa

Executive summary:

The melting point of the test substance was determined under GLP according to EU Method A.1, OECD Guideline 102 and DIN 53736 (method for the determination of melting point) using capillary method. Two main runs were performed, and the mean final temperature was retained.

The melting temperature of test substance has been determined to be 35 ± 1 °C (308 ± 1 K) at 96.7 kPa.

Description of key information

Low melting solid.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
35 °C

Additional information

A reliable experimental study, conducted according to a recognized OECD/EU method and under GLP, is available. Despite minor restrictions due to technical inaccuracy, it is considered as a key study, and the result is retained as key data.