Registration Dossier
Registration Dossier
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EC number: 204-516-9 | CAS number: 122-03-2
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1997
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- PREDICTING MODES OF TOXIC ACTION FROM CHEMICAL STRUCTURE: ACUTE TOXICITY IN THE FATHEAD MINNOW (PIMEPHALES PROMELAS)
- Author:
- CHRISTINE L. RUSSOM, STEVEN P. BRADBURY, STEVEN J. BRODERIUS,
DEAN E. HAMMERMEISTER and ROBERT A. DRUMMOND - Year:
- 1 997
- Bibliographic source:
- Environmental Toxicology and Chemistry, Vol. 16, No. 5, pp. 948–967
Materials and methods
Test guideline
- Guideline:
- other:
- Version / remarks:
- Database for 96-h LC50 values for the fathead minnow, established by US EPA, national Health and Environmental Effects Research laboratory, Duluth, Minnesota. Contains values for approximately 600 chemicals.
- Principles of method if other than guideline:
- The chemical set chosen for study was based on an assessment of the U.S. industrial chemical inventory of discrete organic chemicals.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-isopropylbenzaldehyde
- EC Number:
- 204-516-9
- EC Name:
- 4-isopropylbenzaldehyde
- Cas Number:
- 122-03-2
- Molecular formula:
- C10H12O
- IUPAC Name:
- 4-(propan-2-yl)benzaldehyde
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Chemical cited as p-isopropyl benzaldehyde, CAS 122-03-2, log P = 3.07.
Log of the octanol : water partition coefficient estimated using CLOGPTM program version 3.4 within the UDRIVE system version 3.53, 1988, from Pomona College Medicinal Chemistry
Project, Claremont, CA, USA.
Test organisms
- Test organisms (species):
- Pimephales promelas
Results and discussion
Effect concentrations
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 6.62 mg/L
- Details on results:
- Experimental data in ECOSAR training set (Reference DUL) and OECD toolbox v3.4.0.17.
Original reference (Russom et al, 1997) cited in https://www.epa.gov/sites/production/files/2015-09/documents/ecosartechfinal.pdf and OECD toolbox.
Applicant's summary and conclusion
- Conclusions:
- A published experimental 96h LC50 value of 6.6mg/L is available.
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