Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
other: OECD QSAR Toolbox v4.1 prediction
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
See attached justification

Data source

Reference
Title:
QSAR Toolbox 4.1 prediction for skin sensitisation read-across for 372-18-9
Year:
2017
Bibliographic source:
http://www.oecd.org/

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Data calculated by the QSAR Toolbox.
GLP compliance:
no
Type of study:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-difluorobenzene
EC Number:
206-746-5
EC Name:
1,3-difluorobenzene
Cas Number:
372-18-9
Molecular formula:
C6H4F2
IUPAC Name:
1,3-difluorobenzene
Test material form:
liquid
Details on test material:
Name of the test material: 1,3-difluorobenzene
No data available

In vivo test system

Test animals

Species:
other: no data

Results and discussion

In vivo (LLNA)

Results
Key result
Parameter:
EC3
Remarks on result:
positive indication of skin sensitisation based on QSAR/QSPR prediction

Applicant's summary and conclusion

Interpretation of results:
Category 1B (indication of skin sensitising potential) based on GHS criteria
Conclusions:
According to the prediction obtained with the QSAR Toolbox by read-across, 1-3-difluorobenzene is considered as sensitizing to skin.