Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
other: OECD QSAR Toolbox v4.1 prediction
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
See attached justification

Data source

Reference
Title:
QSAR Toolbox 4.1 prediction for eye irritation read-across for 372-18-9
Year:
2017
Bibliographic source:
http://www.oecd.org/

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Data calculated by the QSAR Toolbox.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-difluorobenzene
EC Number:
206-746-5
EC Name:
1,3-difluorobenzene
Cas Number:
372-18-9
Molecular formula:
C6H4F2
IUPAC Name:
1,3-difluorobenzene
Test material form:
liquid
Details on test material:
Name of the test material: 1,3-difluorobenzene
No data available

Test animals / tissue source

Species:
other: no data

Results and discussion

In vivo

Results
Irritation parameter:
other: Read-across prediction
Remarks on result:
no indication of irritation

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
According to the prediction obtained with the QSAR Toolbox by read-across, 1-3-difluorobenzene is considered as not irritating to eye.

Categories Display