Registration Dossier
Registration Dossier
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EC number: 206-746-5 | CAS number: 372-18-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- other: OECD QSAR Toolbox v4.1 prediction
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- See attached justification
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Data calculated by the QSAR Toolbox.
- GLP compliance:
- no
- Test organisms (species):
- other: Danio rerio
Oncorhynchus mykiss Oryzias latipes Pimephales promelas - Test type:
- not specified
- Total exposure duration:
- 96 h
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 12.7 mg/L
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Toolbox value by trend analysis
- Conclusions:
- The fish toxicity of 1,3-difluorobenzene (1,3-DFB) was determined by trend analysis using the QSAR Toolbox and the 96h LC50 (mortality) of 1,3-DFB to fish was 12.7 mg/L.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- other: OECD QSAR Toolbox v4.1 prediction
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- See attached justification
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Data predicted by the QSAR Toolbox.
- GLP compliance:
- no
- Test organisms (species):
- other: Danio rerio
Oncorhynchus mykiss Oryzias latipes Pimephales promelas - Test type:
- not specified
- Total exposure duration:
- 96 h
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 7.5 mg/L
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Toolbox value by read-across
- Conclusions:
- The fish toxicity of 1,3-difluorobenzene (1,3-DFB) was determined by read-across using the QSAR Toolbox and the 96h LC50 (mortality) of 1,3-DFB to fish was 7.5 mg/L.
Referenceopen allclose all
Description of key information
Two predictions were performed with QSAR Toolbox, one by read-across (96h LC50: 7.5 mg/L), one by trend analysis (96 LC50: 12.7 mg/L).
As a worst case approach, 1,3 -difluorobenzene is considered as toxic for fish.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 7.5 mg/L
Additional information
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
