Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 206-137-4 | CAS number: 303-26-4
Endpoint summary
Administrative data
Description of key information
Bioaccumulation:aquatic/sediments:
Using BCFBAF Program (v3.00) model of EPI suite (2017) the estimated bio concentration factor (BCF) for 1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS No. 303-26-4) is 98.88 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazine is non bioaccumulative in food chain.
Additional information
Bioaccumulation:aquatic/sediments:
Various predicted data for the target compound1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS No. 303-26-4)and supporting weight of evidence study for its read across chemical were reviewed for the bioaccumulation end point which are summarized as below:
First weight of evidence study was done by using BCFBAF Program (v3.00) model of Estimation Program Interface suite (2017) the estimated bio concentration factor (BCF) for 1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS No. 303-26-4) is 98.88 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000.
Next predicted data study was done by using Bio-concentration Factor (v12.1.0.50374) module of(ACD (Advanced Chemistry Development)/I-Lab predictive module, 2017) module in this study theBio-concentration Factor at pH 7 of the chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS no.303 -26 -4) estimated to be 2.88 dimensionless.
Another predicted data study was done by using Scifinder database of(American Chemical Society (ACS), 2017) in this studythe Bioconcentration factor (BCF) of test substance 1-[(4-chlorophenyl)(phenyl)methyl]piperazine at pH 1 -7 range and temperature 25 °C was estimated to be 1 dimensionless and at pH 8, 9 and 10 BCF values was estimate to be 7.18, 49.7 and 125 dimensionless respectively.
Next weight of evidence study was done by Using Chemspider-ACD/Phychem suite prediction model of Royal Society of Chemistry (2017) in this studythe Bioconcentration factor (BCF) for test chemical1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS No: 303-26-4) was predicted in aquatic organisms by at pH 5.5 and pH 7.4.The Bioconcentration factor (BCF) of test substance1-[(4-chlorophenyl)(phenyl)methyl]piperazine at pH 5.5 was estimated to be 1 dimensionless and pH 7.4 was estimated to be 15.06 dimensionless.
Another weight of evidence study was done from CompTox Chemistry Dashboard using OPERA (OPEn (quantitative) structure-activity Relationship Application) V1.02 model in which calculation based on PaDEL descriptors (calculate molecular descriptors and fingerprints of chemical) the bioaccumulation i.e BCF for test substance 1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS no.303 -26 -4) was estimated to be 60.8 dimensionless. The predicted BCF result was based on the 5 OECD principles.
In a supporting weight of evidence study the Bioaccumulation study was conducted on test organism Cyprinus carpio for 6 weeks for evaluating the bioconcentration factor (BCF value) of red across Piperazine (CAS no.110-85-0) from authoritative database (J check, 2017).The study was performed according to other guideline "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances", respectively. Cyprinus carpio was used as a test organism for the study. Read across chemical nominal conc. used for the study were 1mg/l and 0.1 mg/l, respectively. Range finding study involve the TLm (48 hr) ≥ 1000 mg/l (w/v) on Rice fish (Oryzias latipes).The bioconcentration factor (BCF value) of substance Piperazine on Cyprinus carpio was determined to be ≤ 0.3 – 0.9 L/Kg at a conc. of 1 mg/l and ≤ 3.9 L/Kg at a conc. of 0.1 mg/l, respectively, which does not exceed the bioconcentration threshold of 2000, indicating that the red across chemical Piperazine is not expected to bioaccumulate in the food chain.
Last weight of evidence study was also supporting study done from authoritative database (HSDB, 2017) in this study the BCF value of read across chemical 2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid (CAS no. 83881-51-0) estimated was 3 dimensionless by using log Kow of 1.70 and regression derived equation and it is far less than 2000 criteria so it is concluded that test chemical 2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid is non bioaccumulative.
On the basis of above results for target chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS No. 303-26-4) (from EPI suite, ACD labs, Sci Finder database, Chemspider and CompTox Chemistry Dashboard 2017) and for its read across chemicals (From HSDB and J check) it can be concluded that the BCF value of test substance 1-[(4-chlorophenyl)(phenyl)methyl]piperazine ranges from 1-125 dimensionless which does not exceed the bioconcentration threshold of 2000, indicating that the chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazine is expected to be non-bioaccumulative in the food chain
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
