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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from safety assessment report

Data source

Reference
Reference Type:
review article or handbook
Title:
SCREENING-LEVEL HAZARD CHARACTERIZATION
Author:
U.S. Environmental Protection Agency
Year:
2014
Bibliographic source:
U.S. Environmental Protection Agency Hazard Characterization Document September, 2014

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Skin irritation study was conducted in rabbits for test chemical 2-Chloro-p-toluidine-5-sulfonic acid to determine its irritation potential.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
2-Chloro-p-toluidine-5-sulfonic acid
IUPAC Name:
2-Chloro-p-toluidine-5-sulfonic acid
Constituent 2
Reference substance name:
4-amino-6-chlorotoluene-3-sulphonic acid
EC Number:
201-837-6
EC Name:
4-amino-6-chlorotoluene-3-sulphonic acid
Cas Number:
88-51-7
IUPAC Name:
2-amino-4-chloro-5-methylbenzenesulfonic acid
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
- Name of test material (as cited in study report):6-Amino-4-chloro-m-toluenesulfonic acid (2B Acid0
- Molecular formula:C7H8ClNO3S
- Molecular weight :221.6632 g/mol
-Purity:>97%
-Impurities:<3%
- Smiles notation:Cc1cc(c(cc1Cl)N)S(=O)(=O)O
- InChl:1S/C7H8ClNO3S/c1-4-2-7(13(10,11)12)6(9)3-5(4)8/h2-3H,9H2,1H3,(H,10,11,12)
- Substance type:Organic
- Physical state:Solid

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
no data

Test system

Type of coverage:
occlusive
Preparation of test site:
other: Intact site
Vehicle:
other: Saline
Controls:
not specified
Amount / concentration applied:
500mg
Duration of treatment / exposure:
24 hours
Observation period:
48 hours
Number of animals:
6
Details on study design:
no data

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 24 hours
Reversibility:
no data
Remarks on result:
other: slight to mild erythema was seen in 3 animals
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 48 hours
Reversibility:
no data
Remarks on result:
other: slight erythema was seen in 1 animal

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The test material 2-Chloro-p-toluidine-5-sulfonic acid (CAS No: 88-51-7) was observed to be mildly irritating on rabbits skin.
Executive summary:

The skin irritation test was carried out in 6 male albino rabbits of test chemical 2-Chloro-p-toluidine-5-sulfonic acid (CAS No: 88-51-7) to observe its irritation efficacy.

 

Albino rabbits (6 males) were exposed to test chemical in saline via the dermal route to intact skin at 500 mg under occlusive conditions for 24 hours and were observed until 48 hours. At 24 hours, slight to mild erythema was seen in 3 animals and at 48 hours, slight erythema was seen in 1 animal.

 

Hence 2-Chloro-p-toluidine-5-sulfonic acid (CAS No: 88-51-7) can be considered as mildly irritating to the rabbits’ skin.