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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2 August 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
The study was conducted according to an internationally recognised method, and under GLP. No deviation was reported. Test substance is adequately specified. Therefore full validation applies.
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
2009
Deviations:
no
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. certificate)
Remarks:
GLP certificate (inspected on 13 and 14 October 2014 / signed on 08 April 2015)
Type of method:
static method
Key result
Test no.:
#1
Temp.:
ca. 20 °C
Vapour pressure:
ca. 822 Pa
Key result
Test no.:
#2
Temp.:
ca. 25 °C
Vapour pressure:
ca. 1 091 Pa

RESULTS

The calculation results are presented in the following table:

Table 4.6/1: Calculated values for 1/T and log P

n

Temperature T

Pressure P

Temperature T

1/T

log P

 

°C

hPa

K

1/K

log Pa

1

20.0

8.2

293.15

0.00341122

2.9138

2

29.2

14.2

302.35

0.00330743

3.1523

3

38.2

22.6

311.35

0.00321182

3.3541

4

48.0

35.6

321.15

0.00311381

3.5514

5

55.5

50.1

328.65

0.00304275

3.6998

6

45.8

32.8

318.95

0.00313529

3.5159

7

37.1

20.0

310.25

0.00322321

3.3010

8

28.4

13.2

301.55

0.00331620

3.1206

9

21.3

8.8

294.45

0.00339616

2.9445

10

15.1

6.1

288.25

0.00346921

2.7853

The parameters for the linear regression of the graph log (p) vs. 1/T are presented in the following table:

Table 4.6/2: Lienar Regression Parameters

Parameter

Value

Slope

-2147.795685

Intercept

10.24151235

Correlation coefficient r

-0.999517784

r2

0.999035801

Using the equation described above, vapour pressures at ambient temperature were calculated as:

Table 4.6/3: Results vapour pressure

Parameter

Value

Unit

Vapour Pressure (20 °C)

822

Pa

Vapour Pressure (25 °C)

1091

Pa

Conclusions:
The vapour pressure of the test item was calculated as 822 Pa at 20.0 °C and 1091 Pa at 25 °C.
Executive summary:

The vapour pressure of the test substance was measured under GLP according to OECD 104 / EU A4 guideline using the static method.

10 individual measurements of vapour pressure were conducted in a temperature range of 15.1 – 55.5 °C and the pairs of Temperature / Vapour pressure were used to calculate a regression from which vapour pressure at ambient temperature could be interpolated.

Finally, the vapor pressure of the test substance has been determined to be 822 Pa at 20 °C and 1091 Pa at 25 °C.

Note that the result obtained on this kind of substance should be largely influence by small amounts of volatile constituents and these values don't represent the major part of the substance. Therefore the result should be considered with caution when used for subsequent assessment (worst case).

Description of key information

The vapour pressure of the test item was calculated as 822 Pa at 20.0 °C and 1091 Pa at 25 °C. (interpolation).

Key value for chemical safety assessment

Vapour pressure:
822 Pa
at the temperature of:
20 °C

Additional information

A reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. It is considered as a key study.

Note that the result obtained on this kind of substance should be largely influence by small amounts of volatile constituents and these values don't represent the major part of the substance. Therefore the result should be considered with caution when used for subsequent assessment (worst case).