Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
OECD 107

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report Date:
2016

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
additive

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
-4.02
Temp.:
23 °C
pH:
ca. 8.1
Remarks on result:
other: mean of 6 measurements
Remarks:
the value relates to the colouring agent

Any other information on results incl. tables

Table 1: Results

no.

stock solution [mL]

n-octanol [mL]

conc. in n-octanol phase [mg/L]

conc. in water phase [mg/L]

log pow

A1

5

10

0.013

147.2

- 4.05

A2

5

10

0.012

144.7

- 4.08

B1

10

10

0.013

144.7

- 4.05

B2

10

10

0.012

143.7

- 4.08

C1

20

10

0.015

143.6

- 3.98

C2

20

10

0.019

142.6

- 3.87

mean

-

-

-

-

- 4.02

Stock solution: 401 mg/L = 146 mg/L active substance (colouring agent)

The recovery rate of the test substance was between 98 % and 101 %.

Applicant's summary and conclusion