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EC number: 202-235-6 | CAS number: 93-28-7
Penetration of 0.2 mL of test material through excised human epidermis after 72 h was found to be 0.092 ± 0.017 %.
Solubility in water and octanol:
Test material was freely soluble in octanol. Test material exhibited very slight solubility in water (2 to 5 ppm).
A high correlation between water solubility and percentage penetration was observed (r = 0.900, t = 12.040).
In an in vitro skin absorption study, penetration of test material through human epidermis was examined. 0.2 mL of test material was applied to the epidermis attached to the glass tube in a thermostatically controlled cabinet at 21 °C and 55 % relative humidity for 72 h. Seventy-two hours after application of test material, the measurement of penetration was performed by gas chromatography. the solubility of test material in water and octanol was also studied.
Penetration of test material through excised human epidermis after 72 h was found to be 0.092 ± 0.017%. Test material was freely soluble in octanol. Test material exhibited very slight solubility in water (2 - 5 ppm). A high correlation between water solubility and percentage penetration was observed.
This study precedes guideline setting. It is well documented but some methodological aspects make it not reliable: the low temperature (21°C) used in this experiment, the fact that amount within the epidermis was not determined, and the potential loss of test substance through its determination by extraction process rather than radiolabelling may have contributed to the very low penetration rate reported. The integrity of the skin was not checked but in any case a loss of integrity would overestimate the penetration rate.It is therefore considered that the absolute penetration level may not be accurate.
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