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Physical & Chemical properties

Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Experimental dates: September 19, 2017 to September 21, 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
The study was conducted according to an internationally recognized method, and under GLP. No deviation was reported. The test substance is adequately characterised. Therefore full validation applies.
Qualifier:
according to
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Version / remarks:
Regulation (EC) No. 440/2008
Deviations:
no
GLP compliance:
yes (incl. certificate)
Remarks:
inspected on 20 & 21 June 2017 / signed on 04 September 2017
Type of method:
differential scanning calorimetry
Specific details on test material used for the study:
The sample was tested as received. No further preliminary treatment such as drying or milling was performed.
Key result
Melting / freezing pt.:
23.9 °C

No effect was observed during the cooling phase.

The measurements showed an exothermal effect (freezing) during heating up in the temperature range of (-45) to 0°C and an endothermal effect was observed in the temperature range of 20 to 40°C. The onset temperature was derived from the intersection of the tangent line with the highest slope of the endothermal peak with the baseline.

 Assay

 Test item (mg)

 Onset (°C)

 1

 12.70

 23.73

 2

 13.73

 24.07

Duplicate measurements arewithin accuracy (+/- 0.5 °C), therefore the mean value was retained: The test item has a mean melting point of 23.9 °C.

As the test item showed the behaviour of a subcooled melt, the evaluation of the freezing point was not possible.

Executive summary:

The melting point of the test substance was determined under GLP according to OECD 102 / EU A1 guidelines, using Differential Scanning Calorimetry method.

The determination was carried out in duplicate.

Freezing point could not be determined, due to subcooled state.

The mean melting point was measured at 23.9°C.

Description of key information

The melting point (transition from solid to liquid) was measured at 23.9°C.

Freezing point (transition from liquid to solid) could not be determined, due to subcooled state.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
23.9 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. It is considered as a key study, and the result is retained as key data.