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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Study period:
Prior to May 1976
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: early study report; short study description
Justification for type of information:
Read across is based on the category approach. Please refer to attached category document.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report Date:
1976

Materials and methods

Principles of method if other than guideline:
according to BASF-internal standards
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
purity about 90%

Test animals / tissue source

Species:
rabbit
Strain:
Vienna White
Details on test animals or tissues and environmental conditions:
Mean body weight male rabbit: 3.24 kg
Mean body weight female rabbit: 3.21 kg

Test system

Vehicle:
unchanged (no vehicle)
Controls:
other: untreated eye of the same animal
Amount / concentration applied:
0.05 ml
Duration of treatment / exposure:
24 hours
Observation period (in vivo):
8 days
Number of animals or in vitro replicates:
2
Details on study design:
no additional information available.

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 8 days
Score:
0
Irritant / corrosive response data:
After 1 hour slight reddening, secretion; after 24 hours slight reddening, after 8 days no irritation.
Other effects:
No additional information available

Any other information on results incl. tables

No additional information available

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
After 1 hour slight reddening, secretion; after 24 hours slight reddening, after 8 days no irritation.
Executive summary:

The eye irritation potential was examined. After 1 hour slight reddening, secretion; after 24 hours slight reddening, after 8 days no irritation.