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Physical & Chemical properties

Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
1 (reliable without restriction)
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
>= 3.5 - <= 4.2
Temp.:
20 °C
pH:
7

Description of key information

Log Pow >=3.5 <= 4.2 at 20°C (EU A.8, HPLC method)

Log D values (QSAR, SPARC v4.6) 20 deg C:

pH 5: 5.43 to 5.45

pH 7: 3.52 to 3.55

pH 9: 2.66 to 2.69

Key value for chemical safety assessment

Log Kow (Log Pow):
3.5
at the temperature of:
20 °C

Additional information

Key value is taken at pH = 7.