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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: acceptable, well-documented study report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report date:
1987

Materials and methods

Principles of method if other than guideline:
in vivo skin irritation study
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium benzothiazol-2-yl sulphide
EC Number:
219-660-8
EC Name:
Sodium benzothiazol-2-yl sulphide
Cas Number:
2492-26-4
Molecular formula:
C7H4NS2.Na
IUPAC Name:
sodium 2-sulfanylidene-2,3-dihydro-1,3-benzothiazol-3-ide
Details on test material:
sodium MBT, Lot.: 7E090-FP 8085-011-31, 45% solution, pH>12

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
other: intact skin
Vehicle:
unchanged (no vehicle)
Controls:
not required
Duration of treatment / exposure:
4 h
Observation period:
7 days
Number of animals:
6

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 24, 48, 72 h
Score:
8
Max. score:
8
Reversibility:
not reversible
Remarks on result:
other: corrosive, 7 days (injury in depth)
Other effects:
corrosive after 7 days (cratering - injury in depth)

Any other information on results incl. tables

An erythema score of 4 and an edema score of 4 was found 1h, 24h, 48h and 72h in all rabbits after patch removal. After 168 hours reading/scoring was judged as corrosive with cratering and injury in depth.

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information
Executive summary:

Six New Zealand rabbits were applied 0.5 ml of undiluted sodium-mercaptobenzothiazole on the intact skin under semi-occlusive conditions for 4 hours. Skin reactions (erythema and edema) were scored according to Draize 1h, 24 h, 48h, 72 h and 168 h following patch removal.

An erythema score of 4 and an edema score of 4 was found 1h, 24h, 48h and 72h in all rabbits after patch removal. After 168 hours reading/scoring was judged as corrosive with cratering and injury in depth.

Therefor a classification as corrosive to skin (R34 causes burns) according to the classification criteria 67/548/EWG and regulation no. 1272/2008 (GHS) (skin corrosive category 1B, H 314: causes severe skin burns and eye damage) is justified as worst-case consideration because a differentiation between Skin Corrr.1C and Skin Corr.1B is not possible on the basis of the available data.